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    KAT1 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834666, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KAT1
    Official Full Name
    1
    Primary source
    TAIR:AT5G46240
    Locus tag
    AT5G46240
    See related
    Araport:AT5G46240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtKAT1; MPL12.2; MPL12_2; potassium channel in Arabidopsis thaliana 1
    Summary
    Encodes a potassium channel protein (KAT1). ABA triggers KAT1 endocytosis both in epidermal cells as well as guard cells. Upon removal of ABA, KAT1 is recycled back to the plasma membrane. KAT1 is localized within 0.5?0.6 mum diameter microdomains at the plasma membrane surface. KAT1 belongs to the Shaker family K+ channel. This family includes five groups based on phylogenetic analysis (FEBS Letters (2007) 581: 2357): I (inward rectifying channel): AKT1 (AT2G26650), AKT5 (AT4G32500) and SPIK (also known as AKT6, AT2G25600); II (inward rectifying channel): KAT1 (AT5G46240) and KAT2 (AT4G18290); III (weakly inward rectifying channel): AKT2 (AT4G22200); IV (regulatory subunit involved in inwardly rectifying conductance formation): KAT3 (also known as AtKC1, AT4G32650); V (outward rectifying channel): SKOR (AT3G02850) and GORK (AT5G37500).
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    Genomic context

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    See KAT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (18743510..18747406, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene transmembrane protein (DUF616) Neighboring gene hypothetical protein (Protein of unknown function, DUF538) Neighboring gene ncRNA Neighboring gene RNA-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis. Li S, et al. Cell Res, 2020 Nov. PMID 32901112, Free PMC Article
    2. Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae. Anderson JA, et al. Proc Natl Acad Sci U S A, 1992 May 1. PMID 1570292, Free PMC Article
    3. Expression of an inward-rectifying potassium channel by the Arabidopsis KAT1 cDNA. Schachtman DP, et al. Science, 1992 Dec 4. PMID 8966547
    4. Expression of a Cs(+)-resistant guard cell K+ channel confers Cs(+)-resistant, light-induced stomatal opening in transgenic arabidopsis. Ichida AM, et al. Plant Cell, 1997 Oct. PMID 9368418, Free PMC Article
    5. Determination of transmembrane topology of an inward-rectifying potassium channel from Arabidopsis thaliana based on functional expression in Escherichia coli. Uozumi N, et al. Proc Natl Acad Sci U S A, 1998 Aug 18. PMID 9707551, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maternal Embryo Effect Arrest 31 (MEE31) is a moonlighting protein involved in GDP-D-mannose biosynthesis and KAT1 potassium channel regulation.
      Title: Maternal Embryo Effect Arrest 31 (MEE31) is a moonlighting protein involved in GDP-D-mannose biosynthesis and KAT1 potassium channel regulation.
    2. Electromechanical coupling in the hyperpolarization-activated K(+) channel KAT1.
      Title: Electromechanical coupling in the hyperpolarization-activated K(+) channel KAT1.
    3. gating control and K+ uptake leaveraged through membrane anchoring of the trafficking protein SYP121
      Title: Gating control and K(+) uptake by the KAT1 K(+) channel leaveraged through membrane anchoring of the trafficking protein SYP121.
    4. The Arabidopsis K(+) channel KAT1 complements in K(+)-limited medium the growth of the K(+) uptake defective Saccharomyces cerevisiae mutant strain CY162, while another K(+) channel, AKT2, does not.
      Title: Identification of regions responsible for the function of the plant K(+) channels KAT1 and AKT2 in Saccharomyces cerevisiae and Xenopus laevis oocytes.
    5. Data show that in KAT-type K(+) channel KAT1, residue K85 within the linker forms a hydrogen bond with C211 that enables the pH activation.
      Title: The S1-S2 linker determines the distinct pH sensitivity between ZmK2.1 and KAT1.
    6. CPK13 reduces stomatal aperture through its inhibition of the guard cell-expressed KAT2 and KAT1 channels.
      Title: CPK13, a noncanonical Ca2+-dependent protein kinase, specifically inhibits KAT2 and KAT1 shaker K+ channels and reduces stomatal opening.
    7. Plant stress metabolite acrolein inhibits light-induced stomatal opening through inhibition of KAT1 potassium channels in Arabidopsis thaliana.
      Title: Inhibition by acrolein of light-induced stomatal opening through inhibition of inward-rectifying potassium channels in Arabidopsis thaliana.
    8. Mutations of the central Phe residue favored the closed KAT1 channel, whereas mutations affecting the countercharge centers favored the open channel
      Title: Voltage-sensor transitions of the inward-rectifying K+ channel KAT1 indicate a latching mechanism biased by hydration within the voltage sensor.
    9. instead of single key amino acids, several titratable residues contribute to the pH-sensor of the plant Kin channel KAT1
      Title: The pH sensor of the plant K+-uptake channel KAT1 is built from a sensory cloud rather than from single key amino acids.
    10. trafficking of KAT1 has been shown to depend on ER export signals
      Title: Trafficking, lateral mobility and segregation of the plant K channel KAT1.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_123993.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within potassium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1
    NP_199436.1
    • potassium channel in Arabidopsis thaliana 1 (KAT1); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Cyclic nucleotide-binding-like (InterPro:IPR018490), Ion transport (InterPro:IPR005821), Potassium channel, voltage-dependent, EAG/ELK/ERG (InterPro:IPR003938), RmlC-like jelly roll fold (InterPro:IPR014710), Protein of unknown function DUF3354 (InterPro:IPR021789); BEST Arabidopsis thaliana protein match is: potassium channel in Arabidopsis thaliana 2 (TAIR:AT4G18290.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18743510..18747406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123993.3 → NP_199436.1  1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199436.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39128, Q42426
      UniProtKB/TrEMBL
      A0A7G2FG43, Q67YG3
      Conserved Domains (1) summary
      PLN03192
      Location:26 → 677
      PLN03192; Voltage-dependent potassium channel; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39128.2

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