U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RGLG3 Copine (Calcium-dependent phospholipid-binding protein) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836518, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RGLG3
    Official Full Name
    Copine (Calcium-dependent phospholipid-binding protein) family
    Primary source
    TAIR:AT5G63970
    Locus tag
    AT5G63970
    See related
    Araport:AT5G63970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MBM17.7; MBM17_7; RING DOMAIN LIGASE 3
    Summary
    Encodes a ubiquitin ligase that is an essential upstream modulator of JA signaling in response to various stimuli.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RGLG3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (25606771..25609306, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene chromatin remodeling 24 Neighboring gene DNA polymerase delta subunit 1 Neighboring gene SAL1 phosphatase-like protein Neighboring gene Inositol monophosphatase family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4. Zhang X, et al. J Exp Bot, 2015 May. PMID 25788731, Free PMC Article
    2. Two novel RING-type ubiquitin ligases, RGLG3 and RGLG4, are essential for jasmonate-mediated responses in Arabidopsis. Zhang X, et al. Plant Physiol, 2012 Oct. PMID 22898498, Free PMC Article
    3. The Arabidopsis Iron-Sulfur Protein GRXS17 is a Target of the Ubiquitin E3 Ligases RGLG3 and RGLG4. Nagels Durand A, et al. Plant Cell Physiol, 2016 Sep. PMID 27497447
    4. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Fukazawa J, et al. Plant Cell, 2014 Jul. PMID 25035403, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRXS17 is an ubiquitination target of RGLG3 and is ubiquitinated and degraded in a proteasome-dependent manner by RGLG3.
      Title: The Arabidopsis Iron-Sulfur Protein GRXS17 is a Target of the Ubiquitin E3 Ligases RGLG3 and RGLG4.
    2. RGLG3 and RGLG4 have coordinated and positive roles in programmed cell death.
      Title: Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4.
    3. RGLG3 and RGLG4 are essential upstream modulators of jasmonate signaling in response to various stimuli.
      Title: Two novel RING-type ubiquitin ligases, RGLG3 and RGLG4, are essential for jasmonate-mediated responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001037055.1
    NM_125793.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Copine (Calcium-dependent phospholipid-binding protein) family
    NP_001032132.1
    • Copine (Calcium-dependent phospholipid-binding protein) family; FUNCTIONS IN: zinc ion binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase1 (TAIR:AT3G01650.1); Has 1765 Blast hits to 1760 proteins in 138 species: Archae - 0; Bacteria - 0; Metazoa - 1037; Fungi - 2; Plants - 411; Viruses - 37; Other Eukaryotes - 278 (source: NCBI BLink).
    NP_201202.2
    • Copine (Calcium-dependent phospholipid-binding protein) family; FUNCTIONS IN: zinc ion binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase1 (TAIR:AT3G01650.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25606771..25609306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125793.6 → NP_201202.2  Copine (Calcium-dependent phospholipid-binding protein) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201202.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RX26, Q9LVN6
      UniProtKB/TrEMBL
      A0A178U7R6, A0A5S9YGT5, A0A7G2FIN1
      Conserved Domains (3) summary
      COG5574
      Location:267 → 357
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd01459
      Location:14 → 264
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
      cd16729
      Location:322 → 366
      RING-HC_RGLG_plant; RING finger, HC subclass, found in RING domain ligase RGLG1, RGLG2 and similar proteins from plant

    2. NM_001037055.1 → NP_001032132.1  Copine (Calcium-dependent phospholipid-binding protein) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032132.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RX26, Q9LVN6
      UniProtKB/TrEMBL
      A0A178U7R6, A0A5S9YGT5, A0A7G2FIN1
      Conserved Domains (3) summary
      COG5574
      Location:267 → 357
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd01459
      Location:14 → 264
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
      cd16729
      Location:322 → 366
      RING-HC_RGLG_plant; RING finger, HC subclass, found in RING domain ligase RGLG1, RGLG2 and similar proteins from plant
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RX26.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools