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    NPH3 Phototropic-responsive NPH3 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836554, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NPH3
    Official Full Name
    Phototropic-responsive NPH3 family protein
    Primary source
    TAIR:AT5G64330
    Locus tag
    AT5G64330
    See related
    Araport:AT5G64330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    JK218; MSJ1.17; MSJ1_17; NON-PHOTOTROPIC HYPOCOTYL 3; ROOT PHOTOTROPISM 3; RPT3
    Summary
    Involved in blue light response signaling pathway; interacts with the blue light photoreceptor NPH1. Null mutations abolish phototrophic responses of etiolated seedlings to low fluence blue light. Protein contains multiple protein-protein interaction domains.
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    Genomic context

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    See NPH3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (25727126..25730358)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene arabinogalactan protein 1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene transcription factor SAC51 Neighboring gene FK506-binding protein 12 Neighboring gene Chaperone DnaJ-domain superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the NPH1 locus of Arabidopsis disrupt the perception of phototropic stimuli. Liscum E, et al. Plant Cell, 1995 Apr. PMID 7773019, Free PMC Article
    2. Phosphorylation of NONPHOTOTROPIC HYPOCOTYL3 affects photosensory adaptation during the phototropic response. Kimura T, et al. Plant Physiol, 2021 Oct 5. PMID 34608954, Free PMC Article
    3. Deetiolation Enhances Phototropism by Modulating NON-PHOTOTROPIC HYPOCOTYL3 Phosphorylation Status. Sullivan S, et al. Plant Physiol, 2019 Jun. PMID 30918082, Free PMC Article
    4. Light-triggered and phosphorylation-dependent 14-3-3 association with NON-PHOTOTROPIC HYPOCOTYL 3 is required for hypocotyl phototropism. Reuter L, et al. Nat Commun, 2021 Oct 21. PMID 34675219, Free PMC Article
    5. Arabidopsis NPH3: A NPH1 photoreceptor-interacting protein essential for phototropism. Motchoulski A, et al. Science, 1999 Oct 29. PMID 10542152

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of NONPHOTOTROPIC HYPOCOTYL3 affects photosensory adaptation during the phototropic response.
      Title: Phosphorylation of NONPHOTOTROPIC HYPOCOTYL3 affects photosensory adaptation during the phototropic response.
    2. Light-triggered and phosphorylation-dependent 14-3-3 association with NON-PHOTOTROPIC HYPOCOTYL 3 is required for hypocotyl phototropism.
      Title: Light-triggered and phosphorylation-dependent 14-3-3 association with NON-PHOTOTROPIC HYPOCOTYL 3 is required for hypocotyl phototropism.
    3. Regulation of plant phototropic growth by NPH3/RPT2-like substrate phosphorylation and 14-3-3 binding.
      Title: Regulation of plant phototropic growth by NPH3/RPT2-like substrate phosphorylation and 14-3-3 binding.
    4. Tangent algorithm for photogravitropic balance in plants and Phycomyces blakesleeanus: Roles for EHB1 and NPH3 of Arabidopsis thaliana.
      Title: Tangent algorithm for photogravitropic balance in plants and Phycomyces blakesleeanus: Roles for EHB1 and NPH3 of Arabidopsis thaliana.
    5. The continuing arc toward phototropic enlightenment.
      Title: The continuing arc toward phototropic enlightenment.
    6. Deetiolation Enhances Phototropism by Modulating NON-PHOTOTROPIC HYPOCOTYL3 Phosphorylation Status.
      Title: Deetiolation Enhances Phototropism by Modulating NON-PHOTOTROPIC HYPOCOTYL3 Phosphorylation Status.
    7. Phototropic-responsive NPH3 family proteins NPH3 and RPT2 have roles in phototropin 1 (phot1) signaling besides phototropism.
      Title: Shining Light on the Function of NPH3/RPT2-Like Proteins in Phototropin Signaling.
    8. phot2 mediates the stabilization and relocation of NPH3 to the plasma membrane to acclimate to high-intensity blue light.
      Title: Phot2-regulated relocation of NPH3 mediates phototropic response to high-intensity blue light in Arabidopsis thaliana.
    9. The spatial targeting approach therefore excludes the hypocotyl apex as the site for light perception for phototropism and shows that phot1-mediated NPH3 de-phosphorylation is tissue autonomous and occurs more prominently in the basal hypocotyl.
      Title: Functional characterization of Arabidopsis phototropin 1 in the hypocotyl apex.
    10. Data indicate that G-protein beta subunit agb1/nph3 (a regulator of phototropism) double mutants showed no hypocotyl phototropism.
      Title: Arabidopsis G-protein β subunit AGB1 interacts with NPH3 and is involved in phototropism.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001345622.1
    NM_001345623.1
    NM_125829.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blue light signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within blue light signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phototropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    Phototropic-responsive NPH3 family protein
    NP_001318873.1
    • NON-PHOTOTROPIC HYPOCOTYL 3 (NPH3); CONTAINS InterPro DOMAIN/s: NPH3 (InterPro:IPR004249), BTB/POZ fold (InterPro:IPR011333), BTB/POZ-like (InterPro:IPR000210); BEST Arabidopsis thaliana protein match is: Phototropic-responsive NPH3 family protein (TAIR:AT1G30440.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_568989.1
    • NON-PHOTOTROPIC HYPOCOTYL 3 (NPH3); CONTAINS InterPro DOMAIN/s: NPH3 (InterPro:IPR004249), BTB/POZ fold (InterPro:IPR011333), BTB/POZ-like (InterPro:IPR000210); BEST Arabidopsis thaliana protein match is: Phototropic-responsive NPH3 family protein (TAIR:AT1G30440.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25727126..25730358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125829.4 → NP_568989.1  Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568989.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KDL6, F4KDL7, Q0WSP1, Q9FMF5, Q9SPB4
      UniProtKB/TrEMBL
      A0A178UIP8, A0A5S9YGV1, A0A654GE35
      Conserved Domains (3) summary
      smart00225
      Location:55 → 142
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam03000
      Location:250 → 581
      NPH3; NPH3 family
      cl02518
      Location:54 → 154
      BTB; BTB/POZ domain

    2. NM_001345623.1 → NP_001330808.1  Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBW9

    3. NM_001345622.1 → NP_001318873.1  Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2H1ZE95, A0A5S9YGV1, A0A654GE35
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FMF5.2

    Gene LinkOut

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