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    CNGC18 cyclic nucleotide-gated channel 18 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831339, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CNGC18
    Official Full Name
    cyclic nucleotide-gated channel 18
    Primary source
    TAIR:AT5G14870
    Locus tag
    AT5G14870
    See related
    Araport:AT5G14870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCNGC18; cyclic nucleotide-gated channel 18; CYCLIC NUCLEOTIDE-GATED CHANNEL 18; T9L3.170; T9L3_170
    Summary
    Encodes a member of the cyclic nucleotide gated channel family that is asymmetrically localized to the plasma membrane at the growing tip of the pollen tube and is involved in pollen tube growth. It likely directly transduces a cNMP signal into an ion flux that can produce a localized signal capable of regulating the pollen tip-growth machinery.
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    Genomic context

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    See CNGC18 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (4808091..4811093, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Alg9-like mannosyltransferase family Neighboring gene UDP-Glycosyltransferase superfamily protein Neighboring gene Potassium transporter family protein Neighboring gene potassium transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclic nucleotide-gated channel 18 functions as an essential Ca(2+) channel for pollen germination and pollen tube growth in Arabidopsis. Gu LL, et al. Plant Signal Behav, 2017 Nov 2. PMID 27322818, Free PMC Article
    2. Cyclic nucleotide-gated channel 18 is an essential Ca2+ channel in pollen tube tips for pollen tube guidance to ovules in Arabidopsis. Gao QF, et al. Proc Natl Acad Sci U S A, 2016 Mar 15. PMID 26929345, Free PMC Article
    3. Arabidopsis CNGC18 is a Ca²⁺-permeable channel. Gao QF, et al. Mol Plant, 2014 Apr. PMID 24380879
    4. A cyclic nucleotide-gated channel is essential for polarized tip growth of pollen. Frietsch S, et al. Proc Natl Acad Sci U S A, 2007 Sep 4. PMID 17726111, Free PMC Article
    5. A calcium-dependent protein kinase interacts with and activates a calcium channel to regulate pollen tube growth. Zhou L, et al. Mol Plant, 2014 Feb. PMID 24121288

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data demonstrate that CNGC18 plays essential roles in pollen germination and tube growth as a Ca(2+) channel in Arabidopsis.
      Title: Cyclic nucleotide-gated channel 18 functions as an essential Ca(2+) channel for pollen germination and pollen tube growth in Arabidopsis.
    2. Among 8 Ca(2+) channels, CNGC18 was the only one essential for pollen tube guidance. Its transmembrane domains are needed for this function. Point mutations R491Q or R578K resulted in abnormal Ca(2+) gradients and strong pollen tube guidance defects.
      Title: Cyclic nucleotide-gated channel 18 is an essential Ca2+ channel in pollen tube tips for pollen tube guidance to ovules in Arabidopsis.
    3. Arabidopsis CNGC18 is a Ca(2)-permeable channel
      Title: Arabidopsis CNGC18 is a Ca²⁺-permeable channel.
    4. Calcium-activated CPK32 activates CNGC18, further promoting calcium entry during the elevation phase of Ca(2+) oscillations in the polar growth of pollen tub.
      Title: A calcium-dependent protein kinase interacts with and activates a calcium channel to regulate pollen tube growth.
    5. CNGCs have a widespread role in regulating cell-growth dynamics in both plant and animals
      Title: A cyclic nucleotide-gated channel is essential for polarized tip growth of pollen.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121491.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cyclic nucleotide-gated channel 18
    NP_196991.1
    • cyclic nucleotide-gated channel 18 (CNGC18); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channel 16 (TAIR:AT3G48010.1); Has 3357 Blast hits to 3225 proteins in 243 species: Archae - 0; Bacteria - 71; Metazoa - 1532; Fungi - 0; Plants - 967; Viruses - 0; Other Eukaryotes - 787 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4808091..4811093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121491.3 → NP_196991.1  cyclic nucleotide-gated channel 18 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196991.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LEQ3
      UniProtKB/TrEMBL
      A0A178UEB5, A0A5S9Y461
      Conserved Domains (3) summary
      COG0664
      Location:443 → 579
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:449 → 580
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:92 → 378
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LEQ3.1

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