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    NUDX19 nudix hydrolase homolog 19 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832129, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NUDX19
    Official Full Name
    nudix hydrolase homolog 19
    Primary source
    TAIR:AT5G20070
    Locus tag
    AT5G20070
    See related
    Araport:AT5G20070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA NUDIX HYDROLASE HOMOLOG 19; ATNUDT19; ATNUDX19; F28I16.220; F28I16_220; nudix hydrolase homolog 19
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    Genomic context

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    See NUDX19 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (6779841..6782501)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene FAD/NAD(P)-binding oxidoreductase Neighboring gene Uncharacterized protein family (UPF0041) Neighboring gene plant/protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss-of-function of an Arabidopsis NADPH pyrophosphohydrolase, AtNUDX19, impacts on the pyridine nucleotides status and confers photooxidative stress tolerance. Maruta T, et al. Sci Rep, 2016 Nov 22. PMID 27874073, Free PMC Article
    2. Activation of NADPH-recycling systems in leaves and roots of Arabidopsis thaliana under arsenic-induced stress conditions is accelerated by knock-out of Nudix hydrolase 19 (AtNUDX19) gene. Corpas FJ, et al. J Plant Physiol, 2016 Mar 15. PMID 26878367
    3. Arabidopsis thaliana NudiXes have RNA-decapping activity. Mititelu MB, et al. RSC Chem Biol, 2023 Mar 8. PMID 36908703, Free PMC Article
    4. Molecular characterization of organelle-type Nudix hydrolases in Arabidopsis. Ogawa T, et al. Plant Physiol, 2008 Nov. PMID 18815383, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANUDX19 acts as an NADPH pyrophosphohydrolase to modulate cellular levels and redox states of pyridine nucleotides and fine-tunes photooxidative stress response.
      Title: Loss-of-function of an Arabidopsis NADPH pyrophosphohydrolase, AtNUDX19, impacts on the pyridine nucleotides status and confers photooxidative stress tolerance.
    2. The results suggest that AtNUDX19 could be a key factor in modulating the NADPH pool in plants and consequently in redox homeostasis.
      Title: Activation of NADPH-recycling systems in leaves and roots of Arabidopsis thaliana under arsenic-induced stress conditions is accelerated by knock-out of Nudix hydrolase 19 (AtNUDX19) gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_122014.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA decapping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nudix hydrolase homolog 19
    NP_197507.1
    • nudix hydrolase homolog 19 (NUDX19); FUNCTIONS IN: hydrolase activity, metal ion binding; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc ribbon, NADH pyrophosphatase (InterPro:IPR015376), NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase (InterPro:IPR020476), NUDIX hydrolase, conserved site (InterPro:IPR020084), NADH pyrophosphatase-like, N-terminal (InterPro:IPR015375), NUDIX hydrolase domain (InterPro:IPR000086); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6779841..6782501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122014.4 → NP_197507.1  nudix hydrolase homolog 19 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WV54, Q0WVK5, Q94A82
      UniProtKB/TrEMBL
      A0A178UQA0
      Conserved Domains (4) summary
      COG2816
      Location:132 → 418
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
      cd03429
      Location:245 → 420
      NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
      pfam09296
      Location:89 → 205
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:209 → 240
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94A82.1

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