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    INT2 inositol transporter 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839902, updated on 18-Sep-2024

    Summary

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    Official Symbol
    INT2
    Official Full Name
    inositol transporter 2
    Primary source
    TAIR:AT1G30220
    Locus tag
    AT1G30220
    See related
    Araport:AT1G30220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA INOSITOL TRANSPORTER 2; ATINT2; F12P21.2; F12P21_2; inositol transporter 2
    Summary
    Inositol transporter presenting conserved extracellular loop domains homologs of plexins/semaphorin/integrin (PSI) domains from animal type I receptors.
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    Genomic context

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    See INT2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (10632720..10635581, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene TEOSINTE BRANCHED 1, cycloidea, and PCF family 24 Neighboring gene translation elongation factor EF1B/ribosomal protein S6 family protein Neighboring gene proline-, glutamic acid/leucine-rich protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel PSI domains in plant and animal H+-inositol symporters. Dotzauer D, et al. Traffic, 2010 Jun. PMID 20230529
    2. Arabidopsis INOSITOL TRANSPORTER2 mediates H+ symport of different inositol epimers and derivatives across the plasma membrane. Schneider S, et al. Plant Physiol, 2007 Dec. PMID 17951450, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In oocytes, AtINT2 mediated the symport of H(+) and several inositol epimers, such as myoinositol, scylloinositol, d-chiroinositol, and mucoinositol.
      Title: Arabidopsis INOSITOL TRANSPORTER2 mediates H+ symport of different inositol epimers and derivatives across the plasma membrane.
    Submit: New GeneRIF Correction

    General gene information

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    NM_102761.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carbohydrate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables myo-inositol:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myo-inositol:proton symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within myo-inositol transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pollen tube TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inositol transporter 2
    NP_174313.1
    • inositol transporter 2 (INT2); CONTAINS InterPro DOMAIN/s: Sugar transporter, conserved site (InterPro:IPR005829), Major facilitator superfamily (InterPro:IPR020846), General substrate transporter (InterPro:IPR005828), Sugar/inositol transporter (InterPro:IPR003663), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: inositol transporter 4 (TAIR:AT4G16480.1); Has 52249 Blast hits to 41863 proteins in 2438 species: Archae - 698; Bacteria - 26108; Metazoa - 7164; Fungi - 11733; Plants - 4458; Viruses - 2; Other Eukaryotes - 2086 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10632720..10635581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102761.4 → NP_174313.1  inositol transporter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174313.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C757
      UniProtKB/TrEMBL
      A0A178WPB3
      Conserved Domains (2) summary
      cd06174
      Location:33 → 541
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00879
      Location:25 → 552
      SP; MFS transporter, sugar porter (SP) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C757.1

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