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    MSH3 homolog of DNA mismatch repair protein MSH3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828659, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MSH3
    Official Full Name
    homolog of DNA mismatch repair protein MSH3
    Primary source
    TAIR:AT4G25540
    Locus tag
    AT4G25540
    See related
    Araport:AT4G25540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMSH3; homolog of DNA mismatch repair protein MSH3; M7J2.90; M7J2_90
    Summary
    encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH3 heterodimers bound 'insertion-deletion' DNA with three nucleotides (+AAG) or one nucleotide (+T) looped out much better than they bound DNA with a base/base mispair (T/G).
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    Genomic context

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    See MSH3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (13042455..13048262, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene SEUSS-like 3 Neighboring gene SEUSS-like 1 Neighboring gene FLOWERING WAGENINGEN Neighboring gene Cleavage/polyadenylation specificity factor, 25kDa subunit Neighboring gene myb domain protein 18 Neighboring gene Cytochrome b561/ferric reductase transmembrane protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA. Culligan KM, et al. Plant Cell, 2000 Jun. PMID 10852942, Free PMC Article
    2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_118686.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mismatched DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mismatch repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homolog of DNA mismatch repair protein MSH3
    NP_194284.2
    • homolog of DNA mismatch repair protein MSH3 (MSH3); CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695); BEST Arabidopsis thaliana protein match is: MUTS homolog 6 (TAIR:AT4G02070.2); Has 14547 Blast hits to 13713 proteins in 2703 species: Archae - 153; Bacteria - 9793; Metazoa - 705; Fungi - 864; Plants - 451; Viruses - 3; Other Eukaryotes - 2578 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13042455..13048262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118686.3 → NP_194284.2  homolog of DNA mismatch repair protein MSH3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194284.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65607, O81818
      UniProtKB/TrEMBL
      A0A178UVS5, A0A5S9XVR3, A0A654FSW7, A0A7G2F612
      Conserved Domains (1) summary
      COG0249
      Location:99 → 1011
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65607.2

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