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    Dnm3 dynamin 3 [ Mus musculus (house mouse) ]

    Gene ID: 103967, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnm3provided by MGI
    Official Full Name
    dynamin 3provided by MGI
    Primary source
    MGI:MGI:1341299
    See related
    Ensembl:ENSMUSG00000040265 AllianceGenome:MGI:1341299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dyna III; mKIAA0820; C530045C17; 9630020E24Rik; B230343F03Rik
    Summary
    Predicted to enable several functions, including G protein-coupled glutamate receptor binding activity; GTPase activity; and enzyme binding activity. Predicted to be a structural constituent of postsynapse. Involved in synaptic vesicle endocytosis. Located in photoreceptor inner segment. Is active in presynapse. Is expressed in several structures, including 1st branchial arch; central nervous system; genitourinary system; musculature; and paraxial mesenchyme. Orthologous to human DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 19.2), CNS E18 (RPKM 12.1) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dnm3 in Genome Data Viewer
    Location:
    1 H2.1; 1 69.95 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (161810022..162305890, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161982450..162478321, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02830 Neighboring gene RIKEN cDNA 4930558K02 gene Neighboring gene predicted gene, 31925 Neighboring gene STARR-positive B cell enhancer ABC_E4367 Neighboring gene STARR-positive B cell enhancer mm9_chr1:163906574-163906875 Neighboring gene STARR-seq mESC enhancer starr_02833 Neighboring gene RIKEN cDNA 2810442N19 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163930050-163930233 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C Neighboring gene STARR-seq mESC enhancer starr_02834 Neighboring gene VISTA enhancer mm712 Neighboring gene STARR-seq mESC enhancer starr_02835 Neighboring gene STARR-seq mESC enhancer starr_02836 Neighboring gene STARR-seq mESC enhancer starr_02837 Neighboring gene microRNA 199a-2 Neighboring gene dynamin 3, opposite strand Neighboring gene microRNA 214 Neighboring gene STARR-seq mESC enhancer starr_02838 Neighboring gene STARR-seq mESC enhancer starr_02839 Neighboring gene STARR-seq mESC enhancer starr_02840 Neighboring gene predicted gene, 39688 Neighboring gene predicted gene, 31985 Neighboring gene predicted gene, 46247 Neighboring gene methyltransferase 13, eEF1A lysine and N-terminal methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 1 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 5 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of apical tubulobulbar complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    part_of basal tubulobulbar complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dynamin-3
    Names
    dynamin III
    t-dynamin
    testicular dynamin
    NP_001033708.1
    NP_766234.1
    XP_006496664.1
    XP_006496665.1
    XP_006496666.1
    XP_006496667.1
    XP_006496668.1
    XP_030110486.1
    XP_036021487.1
    XP_036021507.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038619.2NP_001033708.1  dynamin-3 isoform 1

      See identical proteins and their annotated locations for NP_001033708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK046124, AK049724, AK147678, AW047427
      UniProtKB/Swiss-Prot
      B2RUH0, Q3UGY9, Q80TR2, Q8BWW6, Q8BZ98
      UniProtKB/TrEMBL
      E9QLL2
      Conserved Domains (6) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:79738
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651739
      GED; Dynamin GTPase effector domain
      pfam15087
      Location:748831
      DUF4551; Protein of unknown function (DUF4551)
    2. NM_172646.3NP_766234.1  dynamin-3 isoform 2

      See identical proteins and their annotated locations for NP_766234.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 2).
      Source sequence(s)
      AK046124, AK049724, AK147678, AW047427
      Consensus CDS
      CCDS48417.1
      UniProtKB/TrEMBL
      E9QLL2
      Related
      ENSMUSP00000064538.8, ENSMUST00000070330.14
      Conserved Domains (6) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:79734
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:647735
      GED; Dynamin GTPase effector domain
      pfam15087
      Location:744827
      DUF4551; Protein of unknown function (DUF4551)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      161810022..162305890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165594.1XP_036021487.1  dynamin-3 isoform X6

      UniProtKB/TrEMBL
      E9QLL2
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:526635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      pfam06346
      Location:753838
      Drf_FH1; Formin Homology Region 1
    2. XM_006496604.5XP_006496667.1  dynamin-3 isoform X4

      UniProtKB/TrEMBL
      E9QLL2
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      PHA03307
      Location:752842
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01256
      Location:526635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:660749
      GED; Dynamin GTPase effector domain
    3. XM_036165614.1XP_036021507.1  dynamin-3 isoform X7

      UniProtKB/TrEMBL
      E9QLL2
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      PHA03247
      Location:738841
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:647735
      GED; Dynamin GTPase effector domain
    4. XM_006496602.4XP_006496665.1  dynamin-3 isoform X2

      UniProtKB/TrEMBL
      E9QLL2
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:526635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam15822
      Location:753841
      MISS; MAPK-interacting and spindle-stabilizing protein-like
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:656745
      GED; Dynamin GTPase effector domain
    5. XM_030254626.2XP_030110486.1  dynamin-3 isoform X5

      UniProtKB/TrEMBL
      E9QLL2
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:526635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam15822
      Location:753843
      MISS; MAPK-interacting and spindle-stabilizing protein-like
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:656745
      GED; Dynamin GTPase effector domain
    6. XM_006496601.4XP_006496664.1  dynamin-3 isoform X1

      UniProtKB/TrEMBL
      E9QLL2
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:526635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam15822
      Location:757845
      MISS; MAPK-interacting and spindle-stabilizing protein-like
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:660749
      GED; Dynamin GTPase effector domain
    7. XM_006496603.5XP_006496666.1  dynamin-3 isoform X3

      UniProtKB/TrEMBL
      E9QLL2
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:526635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam15822
      Location:757847
      MISS; MAPK-interacting and spindle-stabilizing protein-like
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:660749
      GED; Dynamin GTPase effector domain
    8. XM_006496605.4XP_006496668.1  dynamin-3 isoform X8

      Conserved Domains (2) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      pfam01031
      Location:216502
      Dynamin_M; Dynamin central region

    RNA

    1. XR_004942603.1 RNA Sequence

    2. XR_004942591.1 RNA Sequence