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    Hoxb4 homeobox B4 [ Mus musculus (house mouse) ]

    Gene ID: 15412, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hoxb4provided by MGI
    Official Full Name
    homeobox B4provided by MGI
    Primary source
    MGI:MGI:96185
    See related
    Ensembl:ENSMUSG00000038692 AllianceGenome:MGI:96185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hox-2.6
    Summary
    Enables DNA binding activity. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; hematopoietic or lymphoid organ development; and hemopoiesis. Predicted to be located in centrosome. Predicted to be active in nucleoplasm. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; nervous system; and skin. Orthologous to human HOXB4 (homeobox B4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in adrenal adult (RPKM 14.0), genital fat pad adult (RPKM 8.9) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Hoxb4 in Genome Data Viewer
    Location:
    11 D; 11 59.83 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96209093..96212464)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96318267..96321638)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene homeobox B5 and homeobox B6, opposite strand Neighboring gene homeobox B5 Neighboring gene homeobox B3 Neighboring gene Hoxb locus associated lincRNA Neighboring gene microRNA 10a Neighboring gene predicted gene 11536 Neighboring gene homeobox B3 and homeobox B2, opposite strand Neighboring gene homeobox B2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (9)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification  
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of_or_within bone marrow development PubMed 
    acts_upstream_of_or_within definitive hemopoiesis PubMed 
    involved_in embryonic skeletal system morphogenesis  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis PubMed 
    involved_in hematopoietic stem cell differentiation  
    involved_in hematopoietic stem cell differentiation  
    acts_upstream_of_or_within hematopoietic stem cell proliferation PubMed 
    acts_upstream_of_or_within hemopoiesis PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelial sheet PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of stem cell differentiation  
    involved_in positive regulation of stem cell differentiation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within skeletal system morphogenesis PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis PubMed 
    acts_upstream_of_or_within somatic stem cell division PubMed 
    acts_upstream_of_or_within spleen development PubMed 
    Component Evidence Code Pubs
    located_in centrosome  
    located_in centrosome  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    homeobox protein Hox-B4
    Names
    homeo box B4
    homeobox protein Hox-2.6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010459.7NP_034589.3  homeobox protein Hox-B4

      See identical proteins and their annotated locations for NP_034589.3

      Status: VALIDATED

      Source sequence(s)
      AL606824
      Consensus CDS
      CCDS25297.1
      UniProtKB/Swiss-Prot
      P10284, Q3UZB4, Q4VBG0
      Related
      ENSMUSP00000048002.8, ENSMUST00000049241.9
      Conserved Domains (1) summary
      pfam00046
      Location:164218
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96209093..96212464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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