Ptpn11 protein tyrosine phosphatase, non-receptor type 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn11provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 11provided by MGI
Primary source: MGI:MGI:99511
See related: Ensembl:ENSMUSG00000043733 AllianceGenome:MGI:99511
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Syp; Shp2; PTP1D; PTP2C; SAP-2; SHP-2; SH-PTP2; SH-PTP3; 2700084A17Rik
Summary: Enables cell adhesion molecule binding activity; non-membrane spanning protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of chondrocyte differentiation; positive regulation of cytokine production; and positive regulation of ossification. Acts upstream of or within several processes, including cell surface receptor signaling pathway; myeloid cell differentiation; and regulation of hormone secretion. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study several diseases, including Noonan syndrome 1; hepatocellular adenoma; idiopathic scoliosis; intrinsic cardiomyopathy (multiple); and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 24.0), genital fat pad adult (RPKM 23.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 61.72 cM; 5 F

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (121268596..121329460, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (121130533..121191397, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.
Title: SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.
MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells.
Title: MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells.
Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-kappaB- Dependent Inflammation.
Title: Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-κB- Dependent Inflammation.
The low expression of miR-155 promotes the expression of SHP2 by inhibiting the activation of the ERK1/2 pathway and improves cell pyroptosis induced by I/R in mice.
Title: The low expression of miR-155 promotes the expression of SHP2 by inhibiting the activation of the ERK1/2 pathway and improves cell pyroptosis induced by I/R in mice.
Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis.
Title: Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis.
Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution.
Title: Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution.
Hepatic protein tyrosine phosphatase Shp2 disruption mitigates the adverse effects of ethanol in the liver by modulating oxidative stress and ERK signaling.
Title: Hepatic protein tyrosine phosphatase Shp2 disruption mitigates the adverse effects of ethanol in the liver by modulating oxidative stress and ERK signaling.
SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay.
Title: SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay.
Protein Tyrosine Phosphatase SHP2 in Macrophages Acts as an Antiatherosclerotic Regulator in Mice.
Title: Protein Tyrosine Phosphatase SHP2 in Macrophages Acts as an Antiatherosclerotic Regulator in Mice.
Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation.
Title: Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation.

Submit: New GeneRIF Correction See all GeneRIFs (270)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5)
Gene trapped (1)
Targeted (19) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235298

D84372 (e-PCR)
- UniSTS:163370

AW536184 (e-PCR)
- UniSTS:179251

Ptpn11 (e-PCR), detects polymorphism
- UniSTS:536482

Ptpn11 (e-PCR), detects polymorphism
- UniSTS:144300

D84372 (e-PCR)
- UniSTS:124845

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor substrate binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables non-membrane spanning protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Bergmann glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ERBB signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERBB signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular canal development	IEA Inferred from Electronic Annotation more info
involved_in atrioventricular canal development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar cortex formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cerebellar cortex formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in face morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in face morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in genitalia development	IEA Inferred from Electronic Annotation more info
involved_in genitalia development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hormone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in inner ear development	IEA Inferred from Electronic Annotation more info
involved_in inner ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intestinal epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within megakaryocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microvillus organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cortisol secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of growth hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within platelet formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of D-glucose import	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 11

Names: SH2 domain-containing protein tyrosine phosphatase-2; protein-tyrosine phosphatase SYP

NP_001103462.1

EC 3.1.3.48

NP_035332.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109992.1 → NP_001103462.1 tyrosine-protein phosphatase non-receptor type 11 isoform b

See identical proteins and their annotated locations for NP_001103462.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.

Source sequence(s)

AK159501, BC057398, BM899214, CF751511

Consensus CDS

CCDS51637.1

UniProtKB/Swiss-Prot

P35235, Q3TQ84, Q64509, Q6PCL5

Related

ENSMUSP00000098333.3, ENSMUST00000100770.9

Conserved Domains (3) summary

cd09931
Location:111 → 218

SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

cd10340
Location:5 → 103

SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

cd14605
Location:272 → 524

PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11
NM_011202.3 → NP_035332.1 tyrosine-protein phosphatase non-receptor type 11 isoform a

See identical proteins and their annotated locations for NP_035332.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK159501, BC057398, BM899214, CF751511

Consensus CDS

CCDS39247.1

UniProtKB/Swiss-Prot

P35235

Related

ENSMUSP00000058757.8, ENSMUST00000054547.9

Conserved Domains (3) summary

cd09931
Location:111 → 218

SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

cd10340
Location:5 → 103

SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

cd14605
Location:272 → 528

PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11