Nolc1 nucleolar and coiled-body phosphoprotein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nolc1provided by MGI
Official Full Name: nucleolar and coiled-body phosphoprotein 1provided by MGI
Primary source: MGI:MGI:1918019
See related: Ensembl:ENSMUSG00000015176 AllianceGenome:MGI:1918019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P130; NOPP130; NOPP140
Summary: Predicted to enable several functions, including TFIIB-class transcription factor binding activity; snoRNA binding activity; and snoRNP binding activity. Acts upstream of or within nucleolus organization. Located in Cajal body and nucleolus. Is expressed in 1-cell stage embryo; cerebral cortex ventricular layer; and cortical plate. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14 (RPKM 39.7), liver E14.5 (RPKM 31.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 38.75 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (46064286..46073982)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (46075847..46085543)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus.
Title: Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus.
UBF and Nopp140 dynamic redistribution between the two-cell and blastocyst stages (time of implantation) is correlated with morphological and structural modifications that occur in embryonic nucleolar compartments.
Title: Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU046071 (e-PCR)
- UniSTS:160848

RH124297 (e-PCR)
- UniSTS:161119

RH125763 (e-PCR)
- UniSTS:162514

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables TFIIB-class transcription factor binding	ISO Inferred from Sequence Orthology more info
enables box C/D methylation guide snoRNP complex binding	ISO Inferred from Sequence Orthology more info
enables box C/D sno(s)RNA binding	ISO Inferred from Sequence Orthology more info
enables box H/ACA snoRNA binding	ISO Inferred from Sequence Orthology more info
enables box H/ACA snoRNP complex binding	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in box H/ACA sno(s)RNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in neural crest cell development	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest formation	ISO Inferred from Sequence Orthology more info
involved_in neural crest formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nucleolus organization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Cajal body	IDA Inferred from Direct Assay more info	PubMed
part_of box C/D methylation guide snoRNP complex	ISO Inferred from Sequence Orthology more info
part_of box H/ACA snoRNP complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of small nuclear ribonucleoprotein complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: nucleolar and coiled-body phosphoprotein 1

Names: 140 kDa nucleolar phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039351.2 → NP_001034440.1 nucleolar and coiled-body phosphoprotein 1 isoform B

See identical proteins and their annotated locations for NP_001034440.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the central coding region, compared to variant 3. The encoded isoform (B) is shorter, compared to isoform C.

Source sequence(s)

AK029150, AK147118, BE992617, BY031361

Consensus CDS

CCDS89406.1

UniProtKB/TrEMBL

A0A286YDA2, A0A286YDV7

Related

ENSMUSP00000153329.2, ENSMUST00000223728.2

Conserved Domains (1) summary

pfam05022
Location:625 → 691

SRP40_C; SRP40, C-terminal domain
NM_001039352.2 → NP_001034441.1 nucleolar and coiled-body phosphoprotein 1 isoform C

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (C).

Source sequence(s)

AK034817, BE992617, BY031361, CF750495

Consensus CDS

CCDS38006.1

UniProtKB/Swiss-Prot

E9Q5C9, Q3TKZ9, Q3U6W2, Q3UBB6, Q3UI16, Q6ZQK6, Q8CE21

UniProtKB/TrEMBL

A0A286YDV7

Related

ENSMUSP00000128331.2, ENSMUST00000165017.2

Conserved Domains (1) summary

pfam05022
Location:627 → 693

SRP40_C; SRP40, C-terminal domain
NM_001039353.2 → NP_001034442.1 nucleolar and coiled-body phosphoprotein 1 isoform D

See identical proteins and their annotated locations for NP_001034442.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (D) is shorter, compared to isoform C.

Source sequence(s)

AK034817, AK147118, BE992617, BY031361

UniProtKB/TrEMBL

A0A286YDV7

Conserved Domains (1) summary

pfam05022
Location:626 → 692

SRP40_C; SRP40, C-terminal domain
NM_053086.3 → NP_444316.2 nucleolar and coiled-body phosphoprotein 1 isoform A

See identical proteins and their annotated locations for NP_444316.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (A) is shorter, compared to isoform C.

Source sequence(s)

AK147118, AK166753, BE992617, BY031361

Consensus CDS

CCDS89405.1

UniProtKB/TrEMBL

A0A286YDT3, A0A286YDV7

Related

ENSMUSP00000153545.2, ENSMUST00000225780.2

Conserved Domains (1) summary

pfam05022
Location:626 → 692

SRP40_C; SRP40, C-terminal domain