Dcaf13 DDB1 and CUL4 associated factor 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcaf13provided by MGI
Official Full Name: DDB1 and CUL4 associated factor 13provided by MGI
Primary source: MGI:MGI:2684929
See related: Ensembl:ENSMUSG00000022300 AllianceGenome:MGI:2684929
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm83; Wdsof1
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in decidualization; oocyte growth; and rRNA processing. Located in nucleolus. Part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in several structures, including blastocyst; early embryo; and primary oocyte. Orthologous to human DCAF13 (DDB1 and CUL4 associated factor 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in placenta adult (RPKM 20.4), CNS E11.5 (RPKM 18.9) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 15.42 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (38976300..39010251)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (39112874..39146856)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development.
Title: Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development.
The DCAF13-dependent PTEN degradation mechanism fits in as a missing link between CRL4 ubiquitin E3 ligase and PI3K pathway, both of which are crucial for translational activation during oocyte germinal vesicle -metaphase of meiosis II transition.
Title: The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation.
CRL4-DCAF13-mediated SUV39H1 degradation is an essential step for progressive genome reprogramming during preimplantation embryonic development.
Title: DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in decidualization	IDA Inferred from Direct Assay more info	PubMed
involved_in decidualization	ISO Inferred from Sequence Orthology more info
involved_in epigenetic programming in the zygotic pronuclei	IEA Inferred from Electronic Annotation more info
involved_in epigenetic programming in the zygotic pronuclei	ISO Inferred from Sequence Orthology more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in oocyte growth	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in spindle assembly involved in female meiosis	IEA Inferred from Electronic Annotation more info
involved_in spindle assembly involved in female meiosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 13

Names: WD repeat and SOF domain-containing protein 1; WD repeats and SOF domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416064.1 → NP_001402993.1 DDB1- and CUL4-associated factor 13 isoform 2

Status: VALIDATED

Source sequence(s)

AC101886, AC164883
NM_198606.3 → NP_941008.2 DDB1- and CUL4-associated factor 13 isoform 1

See identical proteins and their annotated locations for NP_941008.2

Status: VALIDATED

Source sequence(s)

AC101886, AC164883

Consensus CDS

CCDS37066.1

UniProtKB/Swiss-Prot

E9QPL0, Q6PAC3

Related

ENSMUSP00000022909.9, ENSMUST00000022909.10

Conserved Domains (4) summary

COG2319
Location:1 → 360

WD40; WD40 repeat [General function prediction only]

cd00200
Location:59 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam04158
Location:354 → 438

Sof1; Sof1-like domain

sd00039
Location:70 → 107

7WD40; WD40 repeat [structural motif]