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    Plekha4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 [ Mus musculus (house mouse) ]

    Gene ID: 69217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plekha4provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4provided by MGI
    Primary source
    MGI:MGI:1916467
    See related
    Ensembl:ENSMUSG00000040428 AllianceGenome:MGI:1916467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pepp1; 2410005C22Rik
    Summary
    Predicted to enable identical protein binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in foregut; naris; nervous system; respiratory system cartilage; and turbinate bone primordium. Orthologous to human PLEKHA4 (pleckstrin homology domain containing A4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 7.9), ovary adult (RPKM 6.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plekha4 in Genome Data Viewer
    Location:
    7 B3; 7 29.34 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45175754..45203653)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45526330..45554229)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TUB like protein 2 Neighboring gene nucleobindin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2239 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52781513-52781717 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene predicted gene, 53387 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene STARR-seq mESC enhancer starr_18846 Neighboring gene RIKEN cDNA 0610005C13 gene Neighboring gene STARR-positive B cell enhancer ABC_E3717 Neighboring gene branched chain aminotransferase 2, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 4
    Names
    PEPP-1
    PH domain-containing family A member 4
    phosphoinositol 3-phosphate binding protein-1
    pleckstrin homology domain-containing, family A member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001381849.1 → NP_001368778.1  pleckstrin homology domain-containing family A member 4

      Status: VALIDATED

      Source sequence(s)
      AC151602
      UniProtKB/TrEMBL
      D3YTU1, D3Z3Y7
      Related
      ENSMUSP00000148229.2, ENSMUST00000209517.3
      Conserved Domains (2) summary
      COG1196
      Location:359 → 471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:49 → 152
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    2. NM_148927.2 → NP_683729.2  pleckstrin homology domain-containing family A member 4

      See identical proteins and their annotated locations for NP_683729.2

      Status: VALIDATED

      Source sequence(s)
      AC151602, AV480955, BE652135, BG081030, BY235943, CO044801
      Consensus CDS
      CCDS52248.1
      UniProtKB/TrEMBL
      D3YTU1, D3Z3Y7
      Related
      ENSMUSP00000051468.9, ENSMUST00000051810.15
      Conserved Domains (2) summary
      COG1196
      Location:359 → 471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:49 → 152
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45175754..45203653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541158.3 → XP_006541221.1  pleckstrin homology domain-containing family A member 4 isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:276 → 812
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:411 → 523
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:101 → 204
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    2. XM_006541166.5 → XP_006541229.1  pleckstrin homology domain-containing family A member 4 isoform X7

      UniProtKB/TrEMBL
      A0A1B0GSM9
      Conserved Domains (2) summary
      COG1196
      Location:411 → 523
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:101 → 204
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    3. XM_006541165.4 → XP_006541228.1  pleckstrin homology domain-containing family A member 4 isoform X6

      UniProtKB/TrEMBL
      A0A1B0GSC3
      Related
      ENSMUSP00000147878.2, ENSMUST00000211155.2
      Conserved Domains (2) summary
      COG1196
      Location:411 → 523
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:101 → 204
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    4. XM_006541164.5 → XP_006541227.1  pleckstrin homology domain-containing family A member 4 isoform X5

      Conserved Domains (2) summary
      COG1196
      Location:411 → 523
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:101 → 204
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    5. XM_006541160.4 → XP_006541223.1  pleckstrin homology domain-containing family A member 4 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:276 → 796
      PHA03247; large tegument protein UL36; Provisional
      cd13248
      Location:101 → 204
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02169
      Location:377 → 516
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    6. XM_036153416.1 → XP_036009309.1  pleckstrin homology domain-containing family A member 4 isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:374 → 486
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:64 → 167
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    7. XM_006541163.3 → XP_006541226.1  pleckstrin homology domain-containing family A member 4 isoform X4

      See identical proteins and their annotated locations for XP_006541226.1

      UniProtKB/TrEMBL
      D3YTU1, D3Z3Y7
      Conserved Domains (2) summary
      COG1196
      Location:359 → 471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:49 → 152
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    8. XM_017312284.2 → XP_017167773.1  pleckstrin homology domain-containing family A member 4 isoform X8

      Conserved Domains (1) summary
      COG1196
      Location:227 → 339
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_004934185.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC98.1 GenPept UniProtKB/Swiss-Prot:Q8VC98

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