U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Edil3 EGF-like repeats and discoidin I-like domains 3 [ Mus musculus (house mouse) ]

    Gene ID: 13612, updated on 23-Dec-2024

    Summary

    Official Symbol
    Edil3provided by MGI
    Official Full Name
    EGF-like repeats and discoidin I-like domains 3provided by MGI
    Primary source
    MGI:MGI:1329025
    See related
    Ensembl:ENSMUSG00000034488 AllianceGenome:MGI:1329025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Del1; Del-1; Sox2Cre; Sox2-cre; Tg(Sox2-cre)1Amc
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of or within positive regulation of cell-substrate adhesion. Predicted to be located in extracellular region. Is expressed in several structures, including cartilage; cerebral cortex; heart; skeletal system; and trachea. Orthologous to human EDIL3 (EGF like repeats and discoidin domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 12.8), cerebellum adult (RPKM 11.2) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Edil3 in Genome Data Viewer
    Location:
    13 C3; 13 45.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (88969591..89471344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (88821472..89323225)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35219 Neighboring gene predicted gene, 19139 Neighboring gene predicted gene, 34585 Neighboring gene enolase 2, gamma neuronal pseudogene Neighboring gene STARR-seq mESC enhancer starr_35220 Neighboring gene STARR-seq mESC enhancer starr_35221 Neighboring gene predicted gene, 38504 Neighboring gene stomatin (Epb7.2)-like 2 pseudogene Neighboring gene predicted gene, 46433 Neighboring gene STARR-seq mESC enhancer starr_35222 Neighboring gene STARR-positive B cell enhancer mm9_chr13:89593474-89593775 Neighboring gene predicted gene, 34699 Neighboring gene hyaluronan and proteoglycan link protein 1 Neighboring gene acylglycerol kinase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding  
    Component Evidence Code Pubs
    located_in extracellular region  

    General protein information

    Preferred Names
    EGF-like repeat and discoidin I-like domain-containing protein 3
    Names
    developmental endothelial locus-1
    developmentally-regulated endothelial cell locus 1 protein
    integrin-binding protein DEL1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037987.4NP_001033076.1  EGF-like repeat and discoidin I-like domain-containing protein 3 isoform a precursor

      See identical proteins and their annotated locations for NP_001033076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC121916, AC154668, AC161244, CT010458
      Consensus CDS
      CCDS26669.1
      UniProtKB/Swiss-Prot
      O35474, O35475, Q8CBF7
      Related
      ENSMUSP00000080462.7, ENSMUST00000081769.13
      Conserved Domains (4) summary
      smart00231
      Location:157314
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:119155
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:160313
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00008
      Location:2658
      EGF; EGF-like domain
    2. NM_010103.4NP_034233.1  EGF-like repeat and discoidin I-like domain-containing protein 3 isoform b precursor

      See identical proteins and their annotated locations for NP_034233.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing an internal, in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (b) missing a 10 aa protein segment compared to isoform a.
      Source sequence(s)
      AK046885, AK081003, AK139093, BY701378
      Consensus CDS
      CCDS26670.1
      UniProtKB/TrEMBL
      Q8C4U8
      Related
      ENSMUSP00000044652.7, ENSMUST00000043111.7
      Conserved Domains (4) summary
      smart00231
      Location:147304
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:109145
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:150303
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00008
      Location:2658
      EGF; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      88969591..89471344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.