Nmbr neuromedin B receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nmbrprovided by MGI
Official Full Name: neuromedin B receptorprovided by MGI
Primary source: MGI:MGI:1100525
See related: Ensembl:ENSMUSG00000019865 AllianceGenome:MGI:1100525
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable neuropeptide receptor activity. Involved in several processes, including antiviral innate immune response; negative regulation of interleukin-6 production; and positive regulation of osteoclast proliferation. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in brain; dentate gyrus subgranular zone; lung; lung epithelium; and lung mesenchyme. Orthologous to human NMBR (neuromedin B receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 4.4), frontal lobe adult (RPKM 2.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A2; 10 5.5 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (14634894..14647202)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (14759356..14771458)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of neuromedin B receptor improves mitochondrial oxidative phosphorylation capacity in gastrocnemius muscle of female mice.
Title: Disruption of neuromedin B receptor improves mitochondrial oxidative phosphorylation capacity in gastrocnemius muscle of female mice.
Data show genetically disruption of NB-R in mice ASC or pharmacological antagonism of NB-R in 3T3-L1 cells impairs adipogenesis.
Title: Neuromedin B receptor disruption impairs adipogenesis in mice and 3T3-L1 cells.
NMB-treated mice were less susceptible to virus challenge, as evidenced by increased survival, increased body weight, and decreased viral NP expression compared with the control animals. As expected, opposing effects were observed in the NMBR antagonist-treated cells and mice, which further confirmed the effects of NMB.
Title: Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo.
Neuromedin B expression identifies retrotrapezoid nucleus neurons in the mouse.
Title: Neuromedin B Expression Defines the Mouse Retrotrapezoid Nucleus.
NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK and Akt and induction of D-type cyclins, cyclin D1 and D2.
Title: Neuromedin B and its receptor silencing suppresses osteoclast generation by modulating precursor proliferation via M-CSF/c-Fms/D-type cyclins.
mice with deletion of NB receptor have lower insulinemia, especially in response to oral glucose, and females also exhibited a better glucose tolerance, suggesting the involvement of neuromedin b and its receptor in regulation of insulin secretion induced by incretins, and also, in insulin sensitivity.
Title: Mice with Deletion of Neuromedin B Receptor Exhibit Decreased Oral Glucose-Stimulated Insulin Release.
ablating NMB receptor-expressing neurons eliminated basal and hypoxia-induced sighing, but left breathing otherwise intact initially
Title: The peptidergic control circuit for sighing.
The neuromedin B pathways are importantly involved in secretory pathways of TSH and revealed its participation in the in vivo regulation of gene expression of TSH beta-subunit and pituitary MCT8 and Thrb and hypothalamic TRH and type 2 deiodinase.
Title: Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin B receptor gene.
Together, we define the respective function of NMBR and GRPR in itch transmission, and reveal an unexpected relationship not only between the two receptors but also between the two populations of interneurons in itch signaling.
Title: Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission.
spinal GRPr and NMBr independently drive itch neurotransmission in mice.
Title: Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

Nmbr (e-PCR), detects polymorphism
- UniSTS:498772

BF389161 (e-PCR)
- UniSTS:245392

NoName (e-PCR)
- UniSTS:491261

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bombesin receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in antiviral innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in bombesin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interferon-alpha production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of respiratory gaseous exchange	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sneeze reflex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuromedin-B receptor

Names: NMB-R; neuromedin-B-preferring bombesin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008703.3 → NP_032729.1 neuromedin-B receptor

See identical proteins and their annotated locations for NP_032729.1

Status: VALIDATED

Source sequence(s)

AC111044

Consensus CDS

CCDS23707.1

UniProtKB/Swiss-Prot

O54799

UniProtKB/TrEMBL

Q0VEH1

Related

ENSMUSP00000020015.4, ENSMUST00000020015.10

Conserved Domains (1) summary

pfam00001
Location:60 → 322

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

14634894..14647202

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244941.2 → XP_030100801.1 neuromedin-B receptor isoform X1

Conserved Domains (2) summary

cd14964
Location:16 → 42

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:1 → 273

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily