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    Prkd3 protein kinase D3 [ Mus musculus (house mouse) ]

    Gene ID: 75292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prkd3provided by MGI
    Official Full Name
    protein kinase D3provided by MGI
    Primary source
    MGI:MGI:1922542
    See related
    Ensembl:ENSMUSG00000024070 AllianceGenome:MGI:1922542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PKD3; Pkcnu; Prkcn; 4930557O20Rik; 5730497N19Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; integumental system; musculoskeletal system; and retina. Orthologous to human PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.1), limb E14.5 (RPKM 11.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prkd3 in Genome Data Viewer
    Location:
    17 E3; 17 49.69 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79256834..79328245, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78949405..79020816, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5629 Neighboring gene CCAAT/enhancer binding protein zeta, opposite strand Neighboring gene CCAAT/enhancer binding protein zeta Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene predicted gene, 41622 Neighboring gene STARR-seq mESC enhancer starr_43275 Neighboring gene glutaminyl-peptide cyclotransferase (glutaminyl cyclase) Neighboring gene STARR-seq mESC enhancer starr_43276 Neighboring gene STARR-seq mESC enhancer starr_43277 Neighboring gene STARR-seq mESC enhancer starr_43278 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. T cell-intrinsic protein kinase D3 is dispensable for the cells' activation. Koutník J, et al. Front Immunol, 2022. PMID 36466811, Free PMC Article
    2. Addressing the role of PKD3 in the T cell compartment with knockout mice. Koutník J, et al. Cell Commun Signal, 2022 Apr 19. PMID 35440091, Free PMC Article
    3. Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection. Veazey JM, et al. Front Immunol, 2020. PMID 33381112, Free PMC Article
    4. Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis. Yuan J, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Jan 1. PMID 33039594, Free PMC Article
    5. Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer. LaValle CR, et al. Mol Cancer Ther, 2012 Jul. PMID 22532599, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein kinase D3 conditional knockout impairs osteoclast formation and increases trabecular bone volume in male mice.
      Title: Protein kinase D3 conditional knockout impairs osteoclast formation and increases trabecular bone volume in male mice.
    2. Protein kinase D3 promotes neutrophil migration during viral infection.
      Title: Protein kinase D3 promotes neutrophil migration during viral infection.
    3. T cell-intrinsic protein kinase D3 is dispensable for the cells' activation.
      Title: T cell-intrinsic protein kinase D3 is dispensable for the cells' activation.
    4. Addressing the role of PKD3 in the T cell compartment with knockout mice.
      Title: Addressing the role of PKD3 in the T cell compartment with knockout mice.
    5. A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism.
      Title: A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism.
    6. Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.
      Title: Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.
    7. Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis.
      Title: Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis.
    8. Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.
      Title: Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.
    9. The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.
      Title: The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.
    10. These data provide new insights of a specific PKD3 signaling pathway by identifying a new function, which has not been identified before.
      Title: PKD3 deficiency causes alterations in microtubule dynamics during the cell cycle.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47171

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase D3
    Names
    nPKC-nu
    protein kinase C nu type
    protein kinase C, nu
    NP_001164475.1
    NP_001164476.1
    NP_083515.2
    XP_030105983.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171004.1 → NP_001164475.1  serine/threonine-protein kinase D3 isoform 1

      See identical proteins and their annotated locations for NP_001164475.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC151293, AC154274, BC089164
      Consensus CDS
      CCDS50185.1
      UniProtKB/TrEMBL
      Q5FWX6
      Related
      ENSMUSP00000113395.2, ENSMUST00000119284.8
      Conserved Domains (6) summary
      smart00220
      Location:580 → 832
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:272 → 321
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:410 → 534
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:572 → 831
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:155 → 204
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:417 → 531
      PH; PH domain

    2. NM_001171005.1 → NP_001164476.1  serine/threonine-protein kinase D3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC151293, AC154274, AK030058
      Consensus CDS
      CCDS50184.1
      UniProtKB/TrEMBL
      D3Z6I0
      Related
      ENSMUSP00000113232.2, ENSMUST00000118768.8
      Conserved Domains (6) summary
      smart00220
      Location:485 → 737
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:177 → 226
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:315 → 439
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:477 → 736
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:60 → 109
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:322 → 436
      PH; PH domain

    3. NM_029239.3 → NP_083515.2  serine/threonine-protein kinase D3 isoform 2

      See identical proteins and their annotated locations for NP_083515.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC151293, AC154274
      Consensus CDS
      CCDS37699.1
      UniProtKB/Swiss-Prot
      Q8K1Y2
      Related
      ENSMUSP00000132004.2, ENSMUST00000168887.8
      Conserved Domains (6) summary
      smart00220
      Location:579 → 831
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:272 → 321
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:410 → 534
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:571 → 830
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:155 → 204
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:417 → 531
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      79256834..79328245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250123.2 → XP_030105983.1  serine/threonine-protein kinase D3 isoform X1

      Conserved Domains (2) summary
      cd01239
      Location:10 → 134
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:172 → 431
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1Y2.1 GenPept UniProtKB/Swiss-Prot:Q8K1Y2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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