U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Surf1 Surfeit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44498, updated on 9-Dec-2024

    Summary

    Official Symbol
    Surf1provided by FlyBase
    Official Full Name
    Surfeit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029117
    Locus tag
    Dmel_CG9943
    See related
    AllianceGenome:FB:FBgn0029117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH23574; CG9943; Dmel\CG9943; SUR1
    Summary
    Involved in several processes, including mitochondrial respirasome assembly; phototaxis; and visual behavior. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in adult head. Used to study Leigh disease and mitochondrial complex IV deficiency nuclear type 1. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4K; Leigh disease; and mitochondrial complex IV deficiency nuclear type 1. Orthologous to human SURF1 (SURF1 cytochrome c oxidase assembly factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Surf1 in Genome Data Viewer
    Location:
    65D4-65D4; 3-18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6958346..6959586)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6951446..6952686)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase complex assembly factor 1 Neighboring gene sugarless Neighboring gene uncharacterized protein Neighboring gene Mis12

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in membrane  
    located_in mitochondrial inner membrane PubMed 
    is_active_in mitochondrion  

    General protein information

    Preferred Names
    surfeit 1
    Names
    CG9943-PA
    Surf1-PA
    surfeit locus protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6958346..6959586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080019.3 → NP_524758.1  surfeit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524758.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSH4, Q9U4F3, Q9VRZ8
      UniProtKB/TrEMBL
      C3KGL8
      Related
      FBpp0076607
      Conserved Domains (1) summary
      cd06662
      Location:74 → 289
      SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...
    External link. Please review our privacy policy.