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    Dnaaf4 Dynein axonemal assembly factor 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34547, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dnaaf4provided by FlyBase
    Official Full Name
    Dynein axonemal assembly factor 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032345
    Locus tag
    Dmel_CG14921
    See related
    AllianceGenome:FB:FBgn0032345
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14921; Dmel\CG14921
    Summary
    Involved in axonemal dynein complex assembly and sensory perception of sound. Part of R2TP complex. Is active in cytosol. Is expressed in several structures, including Johnston organ; chordotonal neurons; dorsal sensory complex proper primordium; embryonic immature lch5 neuron; and male germline cell. Used to study sensorineural hearing loss. Human ortholog(s) of this gene implicated in dyslexia and primary ciliary dyskinesia 25. Orthologous to human DNAAF4 (dynein axonemal assembly factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Dnaaf4 in Genome Data Viewer
    Location:
    32D4-32D4; 2-44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11120642..11121714, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11120642..11121714, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lethal (2) giant discs 1 Neighboring gene alpha-L-iduronidase Neighboring gene Gustatory receptor 32a Neighboring gene uncharacterized protein Neighboring gene Csl4 Neighboring gene Nucleoporin 160kD Neighboring gene Replication factor C 38kD subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6. Lennon J, et al. Front Genet, 2022. PMID 35873488, Free PMC Article
    2. Genetic dissection of Nucleoporin 160 (Nup160), a gene involved in multiple phenotypes of reproductive isolation in Drosophila. Maehara K, et al. Genes Genet Syst, 2012. PMID 22820383
    3. Introgression of Drosophila simulans nuclear pore protein 160 in Drosophila melanogaster alone does not cause inviability but does cause female sterility. Sawamura K, et al. Genetics, 2010 Oct. PMID 20647504, Free PMC Article
    4. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article
    5. The RNA-binding protein Arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle. Spletter ML, et al. EMBO Rep, 2015 Feb. PMID 25532219, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of R2TP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein axonemal assembly factor 4
    Names
    CG14921-PA
    Dnaaf4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11120642..11121714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135647.3 → NP_609491.1  dynein axonemal assembly factor 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609491.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKJ5
      Related
      FBpp0079814
      Conserved Domains (1) summary
      cd06469
      Location:4 → 81
      p23_DYX1C1_like; p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKJ5 Q9VKJ5

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