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    CG3251 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33671, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG3251provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031622
    Locus tag
    Dmel_CG3251
    See related
    AllianceGenome:FB:FBgn0031622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3251
    Summary
    Predicted to enable K63-linked deubiquitinase activity and serine-type peptidase activity. Involved in regulation of apoptotic process. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 36. Orthologous to several human genes including OTUD4 (OTU deubiquitinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3251 in Genome Data Viewer
    Location:
    25A3-25A3; 2-13 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4688965..4690702, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4688965..4690702, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Early boundary activity 1 Neighboring gene Early boundary activity 3 Neighboring gene decima Neighboring gene TBP-associated factor 30kD subunit alpha-2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family. Louis M, et al. PLoS One, 2015. PMID 26588485, Free PMC Article
    2. Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Fernández-Espartero CH, et al. Development, 2018 Nov 12. PMID 30333215, Free PMC Article
    3. The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy. Pai YL, et al. Cell Death Dis, 2023 Aug 22. PMID 37607937, Free PMC Article
    4. Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster. Páhi ZG, et al. Sci Rep, 2022 Apr 7. PMID 35393473, Free PMC Article
    5. A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling. Zhang J, et al. G3 (Bethesda), 2012 Dec. PMID 23275879, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3251-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4688965..4690702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135007.2 → NP_608851.1  uncharacterized protein Dmel_CG3251 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VR20
      Related
      FBpp0077113
      Conserved Domains (1) summary
      cl19932
      Location:36 → 115
      OTU; OTU-like cysteine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR20 Q9VR20

    Gene LinkOut

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