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    Hesr HES-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32800, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hesrprovided by FlyBase
    Official Full Name
    HES-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030899
    Locus tag
    Dmel_CG5927
    See related
    AllianceGenome:FB:FBgn0030899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHc21; CG5927; Dmel\CG5927; Her
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human HES2 (hes family bHLH transcription factor 2) and HES4 (hes family bHLH transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hesr in Genome Data Viewer
    Location:
    17A2-17A2; 1-60 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18204403..18205144, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18098436..18099177, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Frequenin 1 Neighboring gene andorra Neighboring gene Frequenin 2 Neighboring gene uncharacterized protein Neighboring gene Holes in muscle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genomewide survey of basic helix-loop-helix factors in Drosophila. Moore AW, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973473, Free PMC Article
    2. The transcription factor Hey and nuclear lamins specify and maintain cell identity. Flint Brodsly N, et al. Elife, 2019 Jul 16. PMID 31310235, Free PMC Article
    3. The two Tribolium E(spl) genes show evolutionarily conserved expression and function during embryonic neurogenesis. Kux K, et al. Mech Dev, 2013 Apr-May. PMID 23485410
    4. Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. Jennings BH, et al. Mol Cell, 2006 Jun 9. PMID 16762837
    5. The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis. Barry KC, et al. Development, 2011 May. PMID 21486924, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HES-related
    Names
    CG5927-PA
    Hesr-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18204403..18205144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080355.2 → NP_525094.1  HES-related [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525094.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWX7
      Related
      FBpp0074362
      Conserved Domains (2) summary
      cd00083
      Location:21 → 77
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cl02638
      Location:101 → 116
      Hairy_orange; Hairy Orange
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWX7 Q9VWX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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