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    Dhc62B Dynein heavy chain at 62B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhc62Bprovided by FlyBase
    Official Full Name
    Dynein heavy chain at 62Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013811
    Locus tag
    Dmel_CG15804
    See related
    AllianceGenome:FB:FBgn0013811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15804; CG18613; dhc; Dhc; DHC; DHC7C; Dmel\CG15804
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in flagellated sperm motility and retrograde axonal transport. Is active in sperm flagellum. Is expressed in chordotonal neurons; chordotonal organ precursor cell; spermatogonium; spermatozoon; and testis. Orthologous to human DNAH12 (dynein axonemal heavy chain 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dhc62B in Genome Data Viewer
    Location:
    62B1-62B3; 3-1.0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1759172..1771758, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1759172..1771758, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Glycerol kinase 2 Neighboring gene uncharacterized protein Neighboring gene Chitinase 2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44351 Neighboring gene uncharacterized protein Neighboring gene DNA polymerase delta subunit 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A family of dynein genes in Drosophila melanogaster. Rasmusson K, et al. Mol Biol Cell, 1994 Jan. PMID 8186464, Free PMC Article
    2. The Y chromosomal fertility factor Threads in Drosophila hydei harbors a functional gene encoding an axonemal dynein beta heavy chain protein. Kurek R, et al. Genetics, 1998 Jul. PMID 9649526, Free PMC Article
    3. A force balance model of early spindle pole separation in Drosophila embryos. Cytrynbaum EN, et al. Biophys J, 2003 Feb. PMID 12547760, Free PMC Article
    4. The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly. Zur Lage P, et al. Biol Open, 2021 Oct 15. PMID 34553759, Free PMC Article
    5. In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis. Basto R, et al. Curr Biol, 2004 Jan 6. PMID 14711415

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein heavy chain at 62B
    Names
    CG15804-PC
    Dhc62B-PC
    dynein heavy chain 62B
    dynein-related heavy chain polypeptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1759172..1771758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206236.3 → NP_995958.2  dynein heavy chain at 62B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995958.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVA7
      Conserved Domains (5) summary
      pfam03028
      Location:3253 → 3952
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:678 → 1102
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2524 → 2864
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:2898 → 3111
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1239 → 1469
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVA7 Q7KVA7
    Q86NT8 Q86NT8
    V9GZM8 V9GZM8

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