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    Cpr49Ae Cuticular protein 49Ae [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36351, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Cpr49Aeprovided by FlyBase
    Official Full Name
    Cuticular protein 49Aeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033728
    Locus tag
    Dmel_CG8505
    See related
    AllianceGenome:FB:FBgn0033728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8505; DmelCpr49Ae; Dmel\CG8505
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in several structures, including adult head; adult heart; embryonic head epidermis; embryonic salivary gland duct; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cpr49Ae in Genome Data Viewer
    Location:
    49A2-49A2; 2-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12402216..12405108)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8289721..8292613)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 49a Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 49Af Neighboring gene Cuticular protein 49Ag

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila. Najarro MA, et al. PLoS Genet, 2015 Nov. PMID 26619284, Free PMC Article
    2. Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion. Kozlova T, et al. Dev Dyn, 2009 Mar. PMID 19235727, Free PMC Article
    3. Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging. Kuintzle RC, et al. Nat Commun, 2017 Feb 21. PMID 28221375, Free PMC Article
    4. Drosophila P elements preferentially transpose to replication origins. Spradling AC, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21896744, Free PMC Article
    5. Label-free quantitative mass spectrometry analysis of the circadian proteome of Drosophila melanogaster lethal giant larvae mutants reveals potential therapeutic effects of melatonin. Wong KC, et al. Arch Insect Biochem Physiol, 2023 Jun. PMID 36915983

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cuticular protein 49Ae
    Names
    CG8505-PA
    Cpr49Ae-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12402216..12405108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136930.4 → NP_610774.3  cuticular protein 49Ae [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610774.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RB2, Q9V6B0
      Related
      FBpp0087031
      Conserved Domains (1) summary
      pfam00379
      Location:43 → 101
      Chitin_bind_4; Insect cuticle protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RB2 Q95RB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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