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    bkdA1 2-oxoisovalerate dehydrogenase subunit alpha [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 877901, updated on 24-Aug-2024

    Summary

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    Gene symbol
    bkdA1
    Gene description
    2-oxoisovalerate dehydrogenase subunit alpha
    Locus tag
    PA2247
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2473213..2474445)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Bkd operon transcriptional regulator BkdR Neighboring gene 2-oxoisovalerate dehydrogenase subunit beta Neighboring gene branched-chain alpha-keto acid dehydrogenase complex lipoamide acyltransferase Neighboring gene branched-chain alpha-keto acid dehydrogenase complex dihydrolipoyl dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Similarity of the E1 subunits of branched-chain-oxoacid dehydrogenase from Pseudomonas putida to the corresponding subunits of mammalian branched-chain-oxoacid and pyruvate dehydrogenases. Burns G, et al. Eur J Biochem, 1988 Sep 15. PMID 3416875
    2. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    3. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    4. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article
    5. A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. Salunkhe P, et al. J Bacteriol, 2005 Jul. PMID 15995206, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within oxoacid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-oxoisovalerate dehydrogenase subunit alpha
    NP_250937.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2473213..2474445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250937.1 2-oxoisovalerate dehydrogenase subunit alpha [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250937.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9I1M2
      Conserved Domains (2) summary
      COG1071
      Location:52 → 409
      AcoA; TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]
      pfam12573
      Location:5 → 45
      OxoDH_E1alpha_N; 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I1M2.1

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