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    qscR quorum-sensing control repressor [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 880650, updated on 24-Aug-2024

    Summary

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    Gene symbol
    qscR
    Gene description
    quorum-sensing control repressor
    Locus tag
    PA1898
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2069490..2070203)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene phenazine biosynthesis protein PhzA Neighboring gene phenazine biosynthesis protein PhzB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression. Liang H, et al. J Bacteriol, 2012 Jun. PMID 22505688, Free PMC Article
    2. 2,5-Piperazinedione inhibits quorum sensing-dependent factor production in Pseudomonas aeruginosa PAO1. Musthafa KS, et al. J Basic Microbiol, 2012 Dec. PMID 22359266
    3. Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor. Lintz MJ, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21911405, Free PMC Article
    4. Acyl-homoserine lactone binding to and stability of the orphan Pseudomonas aeruginosa quorum-sensing signal receptor QscR. Oinuma K, et al. J Bacteriol, 2011 Jan. PMID 21097632, Free PMC Article
    5. Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor. Lee JH, et al. Mol Microbiol, 2006 Jan. PMID 16390453

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors conclude that QscR acts to modulate quorum sensing through regulation of the qscR, PA1895 to PA1897 operon, apparently raising the quorum sensing threshold of the population and providing a "brake" on quorum sensing autoinduction.
      Title: The Pseudomonas aeruginosa Orphan Quorum Sensing Signal Receptor QscR Regulates Global Quorum Sensing Gene Expression by Activating a Single Linked Operon.
    2. The potential of 2,5-piperazinedione in reducing the QS-dependent phenotypic features of PAO1.
      Title: 2,5-Piperazinedione inhibits quorum sensing-dependent factor production in Pseudomonas aeruginosa PAO1.
    3. Using a qscR-lux reporter assay and Northern blot hybridization, we found that the transcription level of qscR increased 4-fold in the vqsR deletion strain compared to the wild-type PAO1 strain, indicating vqsR as a negative regulator of qscR.
      Title: The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression.
    4. Data show that the QscR dimer appears poised to bind DNA.
      Title: Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor.
    5. These data support a model whereby QscR polypeptides fold properly in the absence of an acyl-homoserine lactone, but soluble, acyl-homoserine lactone-free QscR does not accumulate because it is subject to rapid aggregation or proteolysis.
      Title: Acyl-homoserine lactone binding to and stability of the orphan Pseudomonas aeruginosa quorum-sensing signal receptor QscR.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of secondary metabolite biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within quorum sensing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    quorum-sensing control repressor
    NP_250589.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2069490..2070203
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250589.1 quorum-sensing control repressor [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250589.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G3XD77, Q9RMS5
      Conserved Domains (2) summary
      smart00421
      Location:174 → 230
      HTH_LUXR; helix_turn_helix, Lux Regulon
      pfam03472
      Location:17 → 160
      Autoind_bind; Autoinducer binding domain
    Nucleotide Protein
    Heading Accession and Version

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