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    dsc5 UBA/UAS domain-containing protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539260, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dsc5
    Official Full Name
    UBA/UAS domain-containing protein
    Primary source
    PomBase:SPCC285.11
    Locus tag
    SPOM_SPCC285.11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ucp10
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    Genomic context

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    See dsc5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1816085..1818403)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SPRY domain membrane protein, specificity factor required for ubiquitination Ear1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U6 snRNP-associated protein Lsm7 Neighboring gene nucleoporin Nup60 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proximity-dependent biotin labelling in yeast using the engineered ascorbate peroxidase APEX2. Hwang J, et al. Biochem J, 2016 Aug 15. PMID 27274088, Free PMC Article
    2. Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors. Burr R, et al. J Biol Chem, 2017 Mar 31. PMID 28202541, Free PMC Article
    3. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. Raychaudhuri S, et al. J Biol Chem, 2015 Jun 5. PMID 25918164, Free PMC Article
    4. Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. Chong R, et al. J Biol Chem, 2013 Jul 12. PMID 23729666, Free PMC Article
    5. Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. Stewart EV, et al. J Biol Chem, 2012 Jan 2. PMID 22086920, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SREBP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Dsc E3 ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UBA/UAS domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1816085..1818403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023330.3 → NP_588339.1  UBA/UAS domain-containing protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588339.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74498
      Conserved Domains (2) summary
      smart00594
      Location:111 → 237
      UAS; UAS domain
      pfam00789
      Location:322 → 425
      UBX; UBX domain
    Nucleotide Protein
    Heading Accession and Version

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