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    Il17rb interleukin 17 receptor B [ Mus musculus (house mouse) ]

    Gene ID: 50905, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il17rbprovided by MGI
    Official Full Name
    interleukin 17 receptor Bprovided by MGI
    Primary source
    MGI:MGI:1355292
    See related
    Ensembl:ENSMUSG00000015966 AllianceGenome:MGI:1355292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evi27; Il17br; IL-17ER; IL17RH1; IL-17Rh1
    Summary
    Predicted to enable interleukin-17 receptor activity. Acts upstream of or within positive regulation of inflammatory response; positive regulation of interleukin-13 production; and positive regulation of interleukin-5 production. Located in cell surface and cytoplasm. Is expressed in thymus primordium. Orthologous to human IL17RB (interleukin 17 receptor B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 14.9), subcutaneous fat pad adult (RPKM 7.0) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Il17rb in Genome Data Viewer
    Location:
    14 A3; 14 18.39 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (29718125..29730853, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (29996168..30008896, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:30781377-30781530 Neighboring gene selenoprotein K Neighboring gene ARP8 actin-related protein 8 Neighboring gene microRNA 6947 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:30823404-30823587 Neighboring gene choline dehydrogenase Neighboring gene predicted gene, 35449 Neighboring gene corepressor interacting with RBPJ, 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (9)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-17 receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-17 receptor B
    Names
    IL-17 receptor B
    IL-17 receptor homolog 1
    IL-17B receptor
    IL-17RB
    ecotropic viral integration site 27
    interleukin 17B receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019583.3NP_062529.2  interleukin-17 receptor B precursor

      See identical proteins and their annotated locations for NP_062529.2

      Status: PROVISIONAL

      Source sequence(s)
      AK045627
      Consensus CDS
      CCDS36845.1
      UniProtKB/Swiss-Prot
      Q9JIP2, Q9JIP3
      UniProtKB/TrEMBL
      D3Z4T0, Q543U7
      Related
      ENSMUSP00000016110.7, ENSMUST00000016110.13
      Conserved Domains (2) summary
      pfam08357
      Location:329476
      SEFIR; SEFIR domain
      pfam16556
      Location:33175
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      29718125..29730853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247884.1XP_030103744.1  interleukin-17 receptor B isoform X1

      Conserved Domains (1) summary
      pfam08357
      Location:102249
      SEFIR; SEFIR domain