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    MASTL microtubule associated serine/threonine kinase like [ Homo sapiens (human) ]

    Gene ID: 84930, updated on 10-Dec-2024

    Summary

    Official Symbol
    MASTLprovided by HGNC
    Official Full Name
    microtubule associated serine/threonine kinase likeprovided by HGNC
    Primary source
    HGNC:HGNC:19042
    See related
    Ensembl:ENSG00000120539 MIM:608221; AllianceGenome:HGNC:19042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GW; GWL; THC2; MAST-L; GREATWALL
    Summary
    This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 4.9), testis (RPKM 3.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MASTL in Genome Data Viewer
    Location:
    10p12.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (27154479..27187953)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (27184483..27217949)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (27444281..27476882)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain containing 26 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2243 Neighboring gene RNA, U6 small nuclear 490, pseudogene Neighboring gene YME1 like 1 ATPase Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3180 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:27444170-27444368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3181 Neighboring gene RNA, U2 small nuclear 24, pseudogene Neighboring gene acyl-CoA binding domain containing 5 Neighboring gene RNA, U7 small nuclear 12 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14813

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein phosphatase 2A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female meiosis II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase greatwall
    Names
    greatwall kinase homolog
    greatwall protein kinase
    NP_001165774.1
    NP_001165775.1
    NP_001307685.1
    NP_001307686.1
    NP_001358958.1
    NP_001358959.1
    NP_116233.2
    XP_005252688.1
    XP_005252689.1
    XP_006717582.1
    XP_006717583.1
    XP_011518053.1
    XP_016872341.1
    XP_016872342.1
    XP_016872344.1
    XP_024304011.1
    XP_024304012.1
    XP_047281872.1
    XP_047281873.1
    XP_047281874.1
    XP_047281875.1
    XP_047281876.1
    XP_054223009.1
    XP_054223010.1
    XP_054223011.1
    XP_054223012.1
    XP_054223013.1
    XP_054223014.1
    XP_054223015.1
    XP_054223016.1
    XP_054223017.1
    XP_054223018.1
    XP_054223019.1
    XP_054223020.1
    XP_054223021.1
    XP_054223022.1
    XP_054223023.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016987.1 RefSeqGene

      Range
      5529..38130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172303.3NP_001165774.1  serine/threonine-protein kinase greatwall isoform 1

      See identical proteins and their annotated locations for NP_001165774.1

      Status: REVIEWED

      Source sequence(s)
      AL160291
      Consensus CDS
      CCDS53502.1
      UniProtKB/Swiss-Prot
      Q5T8D5, Q5T8D7, Q8NCD6, Q96GX5, Q96SJ5
      Related
      ENSP00000365107.5, ENST00000375940.9
      Conserved Domains (3) summary
      COG0515
      Location:34399
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:709870
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001172304.3NP_001165775.1  serine/threonine-protein kinase greatwall isoform 3

      See identical proteins and their annotated locations for NP_001165775.1

      Status: REVIEWED

      Source sequence(s)
      AL160291
      Consensus CDS
      CCDS53503.1
      UniProtKB/Swiss-Prot
      Q96GX5
      Related
      ENSP00000343446.5, ENST00000342386.10
      Conserved Domains (3) summary
      COG0515
      Location:34399
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:696831
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001320756.2NP_001307685.1  serine/threonine-protein kinase greatwall isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL160291
      Conserved Domains (3) summary
      COG0515
      Location:34399
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:696874
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001320757.2NP_001307686.1  serine/threonine-protein kinase greatwall isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL160291
      Conserved Domains (3) summary
      COG0515
      Location:34399
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:709875
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001372029.1NP_001358958.1  serine/threonine-protein kinase greatwall isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL160291
      Conserved Domains (1) summary
      cl21453
      Location:548714
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001372030.1NP_001358959.1  serine/threonine-protein kinase greatwall isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL160291
      Conserved Domains (1) summary
      cl21453
      Location:548709
      PKc_like; Protein Kinases, catalytic domain
    7. NM_032844.5NP_116233.2  serine/threonine-protein kinase greatwall isoform 2

      See identical proteins and their annotated locations for NP_116233.2

      Status: REVIEWED

      Source sequence(s)
      AL160291
      Consensus CDS
      CCDS7153.1
      UniProtKB/Swiss-Prot
      Q96GX5
      Related
      ENSP00000365113.4, ENST00000375946.8
      Conserved Domains (3) summary
      COG0515
      Location:34399
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:696869
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_135469.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL160291

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      27154479..27187953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016853.3XP_016872342.1  serine/threonine-protein kinase greatwall isoform X5

    2. XM_047425916.1XP_047281872.1  serine/threonine-protein kinase greatwall isoform X6

    3. XM_047425919.1XP_047281875.1  serine/threonine-protein kinase greatwall isoform X13

    4. XM_047425917.1XP_047281873.1  serine/threonine-protein kinase greatwall isoform X7

    5. XM_047425920.1XP_047281876.1  serine/threonine-protein kinase greatwall isoform X14

    6. XM_006717519.5XP_006717582.1  serine/threonine-protein kinase greatwall isoform X1

      Conserved Domains (3) summary
      COG0515
      Location:34399
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:709841
      PKc_like; Protein Kinases, catalytic domain
    7. XM_024448243.2XP_024304011.1  serine/threonine-protein kinase greatwall isoform X2

      Conserved Domains (2) summary
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:709836
      PKc_like; Protein Kinases, catalytic domain
    8. XM_005252631.5XP_005252688.1  serine/threonine-protein kinase greatwall isoform X4

      Conserved Domains (3) summary
      COG0515
      Location:34399
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:709832
      PKc_like; Protein Kinases, catalytic domain
    9. XM_005252632.5XP_005252689.1  serine/threonine-protein kinase greatwall isoform X8

      Conserved Domains (3) summary
      COG0515
      Location:34399
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:709798
      PKc_like; Protein Kinases, catalytic domain
    10. XM_017016852.3XP_016872341.1  serine/threonine-protein kinase greatwall isoform X3

    11. XM_024448244.2XP_024304012.1  serine/threonine-protein kinase greatwall isoform X9

      Conserved Domains (2) summary
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:696797
      PKc_like; Protein Kinases, catalytic domain
    12. XM_047425918.1XP_047281874.1  serine/threonine-protein kinase greatwall isoform X11

    13. XM_017016855.3XP_016872344.1  serine/threonine-protein kinase greatwall isoform X12

    14. XM_006717520.5XP_006717583.1  serine/threonine-protein kinase greatwall isoform X10

      Conserved Domains (3) summary
      COG0515
      Location:34399
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd05610
      Location:30223
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:709799
      PKc_like; Protein Kinases, catalytic domain
    15. XM_011519751.3XP_011518053.1  serine/threonine-protein kinase greatwall isoform X15

      UniProtKB/TrEMBL
      A0A087WUU7
      Conserved Domains (1) summary
      cl21453
      Location:372538
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      27184483..27217949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367046.1XP_054223021.1  serine/threonine-protein kinase greatwall isoform X13

    2. XM_054367039.1XP_054223014.1  serine/threonine-protein kinase greatwall isoform X6

    3. XM_054367038.1XP_054223013.1  serine/threonine-protein kinase greatwall isoform X5

    4. XM_054367040.1XP_054223015.1  serine/threonine-protein kinase greatwall isoform X7

    5. XM_054367047.1XP_054223022.1  serine/threonine-protein kinase greatwall isoform X14

    6. XM_054367034.1XP_054223009.1  serine/threonine-protein kinase greatwall isoform X1

    7. XM_054367035.1XP_054223010.1  serine/threonine-protein kinase greatwall isoform X2

    8. XM_054367037.1XP_054223012.1  serine/threonine-protein kinase greatwall isoform X4

    9. XM_054367041.1XP_054223016.1  serine/threonine-protein kinase greatwall isoform X8

    10. XM_054367036.1XP_054223011.1  serine/threonine-protein kinase greatwall isoform X3

    11. XM_054367042.1XP_054223017.1  serine/threonine-protein kinase greatwall isoform X9

    12. XM_054367044.1XP_054223019.1  serine/threonine-protein kinase greatwall isoform X11

    13. XM_054367045.1XP_054223020.1  serine/threonine-protein kinase greatwall isoform X12

    14. XM_054367043.1XP_054223018.1  serine/threonine-protein kinase greatwall isoform X10

    15. XM_054367048.1XP_054223023.1  serine/threonine-protein kinase greatwall isoform X15

      UniProtKB/TrEMBL
      A0A087WUU7