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    CAM1 calmodulin 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833756, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAM1
    Official Full Name
    calmodulin 1
    Primary source
    TAIR:AT5G37780
    Locus tag
    AT5G37780
    See related
    Araport:AT5G37780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACAM-1; calmodulin 1; K22F20.20; K22F20_20; TCH1; TOUCH 1
    Summary
    encodes a calmodulin that is involved in thigmomorphogenesis. Gene expression is rapidly induced upon a variety of abiotic stimuli, including water spray, subirrigation, wind, touch, wounding, or darkness.
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    Genomic context

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    See CAM1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (15004466..15006267, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene EF hand calcium-binding protein family Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calmodulin antagonist affects peroxisomal functionality by disrupting both peroxisomal Ca(2+) and protein import. Corpas FJ, et al. J Cell Sci, 2018 Jan 29. PMID 28183730
    2. Rapid kinetics of calcium dissociation from plant calmodulin and calmodulin-like proteins and effect of target peptides. Troilo F, et al. Biochem Biophys Res Commun, 2022 Jan 29. PMID 34974297
    3. Rain-, wind-, and touch-induced expression of calmodulin and calmodulin-related genes in Arabidopsis. Braam J, et al. Cell, 1990 Feb 9. PMID 2302732
    4. Identification of non-specific lipid transfer protein-1 as a calmodulin-binding protein in Arabidopsis. Wang Z, et al. FEBS Lett, 2005 Mar 14. PMID 15757661
    5. Ca2+/calmodulin is critical for brassinosteroid biosynthesis and plant growth. Du L, et al. Nature, 2005 Sep 29. PMID 16193053

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rapid kinetics of calcium dissociation from plant calmodulin and calmodulin-like proteins and effect of target peptides.
      Title: Rapid kinetics of calcium dissociation from plant calmodulin and calmodulin-like proteins and effect of target peptides.
    2. Ca(2+) and CaM are strictly necessary for protein import and normal functionality of peroxisomal enzymes, including antioxidant and photorespiratory enzymes, as well as for nitric oxide production.
      Title: Calmodulin antagonist affects peroxisomal functionality by disrupting both peroxisomal Ca(2+) and protein import.
    3. Here, the authors determined crystal structures of AtBAG5 alone and in complex with Ca(2+)-free CaM. Structural and biochemical studies revealed that Ca(2+)-free CaM and Hsc70 bind AtBAG5 independently, whereas Ca(2+)-saturated CaM and Hsc70 bind AtBAG5 with negative cooperativity.
      Title: CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence.
    4. mutations in the two lobes affect GAD1 activation in similar ways and only intact AtCaM1 can fully activate GAD1. Taken together, our data provide new insights into the CaM lobes role in interactions between CaM and plant GAD.
      Title: Biochemical and biophysical characterization of a plant calmodulin: Role of the N- and C-lobes in calcium binding, conformational change, and target interaction.
    5. the PPIase activity of the Arabidopsis cyclophilin was not affected by CaM
      Title: Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3.
    6. Ca(2+)/Calmodulin-mediated signaling regulates plant response to herbivore attack/wounding by modulating the salicylic acid-jasmonic acid crosstalk through AtSR1.
      Title: Coupling calcium/calmodulin-mediated signaling and herbivore-induced plant response through calmodulin-binding transcription factor AtSR1/CAMTA3.
    7. Data show that the level of CAM1 and CAM5 gene mRNAs were consistently greater in response to heat stress in both root and shoot.
      Title: Expression of calmodulin genes in wild type and calmodulin mutants of Arabidopsis thaliana under heat stress.
    8. the cytosolic face of ACA8 mediates early CaM recognition and CaM subsequently competes with the intramolecular autoinhibitor in binding to the other face of the helix
      Title: The plant plasma membrane Ca2+ pump ACA8 contains overlapping as well as physically separated autoinhibitory and calmodulin-binding domains.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001161282.1
    NM_001161283.1
    NM_001344219.1
    NM_123137.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within detection of calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    calmodulin 1
    NP_001154754.1
    • calmodulin 1 (CAM1); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 4 (TAIR:AT1G66410.1); Has 30779 Blast hits to 22253 proteins in 1727 species: Archae - 2; Bacteria - 134; Metazoa - 13527; Fungi - 6643; Plants - 6315; Viruses - 0; Other Eukaryotes - 4158 (source: NCBI BLink).
    NP_001154755.1
    • calmodulin 1 (CAM1); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 4 (TAIR:AT1G66410.1); Has 29914 Blast hits to 22079 proteins in 1723 species: Archae - 3; Bacteria - 127; Metazoa - 13080; Fungi - 6590; Plants - 6083; Viruses - 0; Other Eukaryotes - 4031 (source: NCBI BLink).
    NP_198594.1
    • calmodulin 1 (CAM1); FUNCTIONS IN: calcium ion binding; INVOLVED IN: detection of calcium ion, response to mechanical stimulus; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 4 (TAIR:AT1G66410.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      15004466..15006267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123137.4 → NP_198594.1  calmodulin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0DH95, P0DH96, P25854, Q03510, Q9FJ05
      UniProtKB/TrEMBL
      A0A178WBP5, A0A5S9WQ45, A8Y7S8
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 149
      PTZ00184; calmodulin; Provisional

    2. NM_001161283.1 → NP_001154755.1  calmodulin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y7S8, F4K8M2
      Conserved Domains (2) summary
      PTZ00184
      Location:1 → 175
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:111 → 173
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. NM_001161282.1 → NP_001154754.1  calmodulin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y7S8, F4K8M3
      Conserved Domains (2) summary
      PTZ00184
      Location:1 → 164
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:100 → 162
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. NM_001344219.1 → NP_001330399.1  calmodulin 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BAP4, A8Y7S8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DH95.1
    P0DH96.1

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