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    ALY4 ALWAYS EARLY 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833750, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALY4
    Official Full Name
    ALWAYS EARLY 4
    Primary source
    TAIR:AT5G37720
    Locus tag
    AT5G37720
    See related
    Araport:AT5G37720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ALWAYS EARLY 4; AtALY4; DIP2; interacting with DNA-binding domain of Zn-finger PARP 1; K12B20.19; K12B20_19
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    Genomic context

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    See ALY4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (14981619..14984730, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene SGNH hydrolase-type esterase superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ALY proteins participate in multifaceted Nep1Mo-triggered responses in Nicotiana benthamiana and Arabidopsis thaliana. Teng W, et al. J Exp Bot, 2014 Jun. PMID 24723400, Free PMC Article
    2. Arabidopsis coactivator ALY-like proteins, DIP1 and DIP2, interact physically with the DNA-binding domain of the Zn-finger poly(ADP-ribose) polymerase. Storozhenko S, et al. J Exp Bot, 2001 Jun. PMID 11432957
    3. ALY RNA-Binding Proteins Are Required for Nucleocytosolic mRNA Transport and Modulate Plant Growth and Development. Pfaff C, et al. Plant Physiol, 2018 May. PMID 29540591, Free PMC Article
    4. Relocalization of nuclear ALY proteins to the cytoplasm by the tomato bushy stunt virus P19 pathogenicity protein. Uhrig JF, et al. Plant Physiol, 2004 Aug. PMID 15299117, Free PMC Article
    5. Dynamic behavior of Arabidopsis eIF4A-III, putative core protein of exon junction complex: fast relocation to nucleolus and splicing speckles under hypoxia. Koroleva OA, et al. Plant Cell, 2009 May. PMID 19435936, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ALY4 plays a role in mRNA export and that the efficient nucleocytosolic transport of mRNAs is a requirement for proper plant growth and development.
      Title: ALY RNA-Binding Proteins Are Required for Nucleocytosolic mRNA Transport and Modulate Plant Growth and Development.
    2. ALY4 proteins participate in multifaceted Nep1Mo-triggered responses in Arabidopsis thaliana.
      Title: ALY proteins participate in multifaceted Nep1Mo-triggered responses in Nicotiana benthamiana and Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001085207.2
    NM_123131.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ALWAYS EARLY 4
    NP_001078676.1
    • ALWAYS EARLY 4 (ALY4); FUNCTIONS IN: nucleotide binding, nucleic acid binding; INVOLVED IN: biological_process unknown; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT1G66260.2); Has 5809 Blast hits to 5449 proteins in 440 species: Archae - 2; Bacteria - 280; Metazoa - 2763; Fungi - 1142; Plants - 1077; Viruses - 9; Other Eukaryotes - 536 (source: NCBI BLink).
    NP_198588.2
    • ALWAYS EARLY 4 (ALY4); FUNCTIONS IN: nucleotide binding, nucleic acid binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleolus; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT1G66260.2); Has 8810 Blast hits to 7454 proteins in 559 species: Archae - 0; Bacteria - 678; Metazoa - 4105; Fungi - 1555; Plants - 1582; Viruses - 59; Other Eukaryotes - 831 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      14981619..14984730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123131.4 → NP_198588.2  ALWAYS EARLY 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198588.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NQ72, Q9FHP9, Q9LF76
      UniProtKB/TrEMBL
      A0A178UKT9, A0A654G5U7
      Conserved Domains (1) summary
      cd12680
      Location:93 → 167
      RRM_THOC4; RNA recognition motif (RRM) found in THO complex subunit 4 (THOC4) and similar proteins

    2. NM_001085207.2 → NP_001078676.1  ALWAYS EARLY 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078676.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G5U7, A8MQ78
      Conserved Domains (2) summary
      COG0724
      Location:93 → 223
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12680
      Location:93 → 167
      RRM_THOC4; RNA recognition motif in THO complex subunit 4 (THOC4) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NQ72.1

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