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    RASSF8-AS1 RASSF8 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100506451, updated on 22-Oct-2024

    Summary

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    Official Symbol
    RASSF8-AS1provided by HGNC
    Official Full Name
    RASSF8 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:48637
    See related
    Ensembl:ENSG00000246695 AllianceGenome:HGNC:48637
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in kidney (RPKM 4.7), testis (RPKM 3.1) and 20 other tissues See more
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    Genomic context

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    See RASSF8-AS1 in Genome Data Viewer
    Location:
    12p12.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (25954654..25959442, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (25827215..25832006, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (26107587..26112375, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene thymine-DNA glycosylase pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:26038654-26039197 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:26040173-26040831 Neighboring gene microRNA 4302 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4298 Neighboring gene Ras association domain family member 8 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:26150508-26151264 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:26151265-26152021 Neighboring gene uncharacterized LOC107984501 Neighboring gene uncharacterized LOC124902901

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A RASSF8-AS1 based exosomal lncRNAs panel used for diagnostic and prognostic biomarkers for esophageal squamous cell carcinoma. Xie K, et al. Thorac Cancer, 2022 Dec. PMID 36266257, Free PMC Article
    2. RASSF8-AS1 displays low expression in colorectal cancer and up-regulates RASSF8 to suppress cell invasion and migration. Zhang X, et al. Pathol Res Pract, 2022 Sep. PMID 35839610
    3. lncRNA RASSF8‑AS1 suppresses the progression of laryngeal squamous cell carcinoma via targeting the miR‑664b‑3p/TLE1 axis. Liu T, et al. Oncol Rep, 2020 Nov. PMID 33000257, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A RASSF8-AS1 based exosomal lncRNAs panel used for diagnostic and prognostic biomarkers for esophageal squamous cell carcinoma.
      Title: A RASSF8-AS1 based exosomal lncRNAs panel used for diagnostic and prognostic biomarkers for esophageal squamous cell carcinoma.
    2. RASSF8-AS1 displays low expression in colorectal cancer and up-regulates RASSF8 to suppress cell invasion and migration.
      Title: RASSF8-AS1 displays low expression in colorectal cancer and up-regulates RASSF8 to suppress cell invasion and migration.
    3. lncRNA RASSF8AS1 suppresses the progression of laryngeal squamous cell carcinoma via targeting the miR664b3p/TLE1 axis.
      Title: lncRNA RASSF8‑AS1 suppresses the progression of laryngeal squamous cell carcinoma via targeting the miR‑664b‑3p/TLE1 axis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • RASSF8 atnisense RNA 1

    Clone Names

    • FLJ31399

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038227.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      BC004962, BX109355, DA682910
      Related
      ENST00000773032.1

    2. NR_038228.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5'-most exon, and uses an alternate splice site in exon 2, compared to variant 1.
      Source sequence(s)
      BX109355, DA306887, DA682910, DB074156

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      25954654..25959442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      25827215..25832006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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