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    NHSL2 NHS like 2 [ Homo sapiens (human) ]

    Gene ID: 340527, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NHSL2provided by HGNC
    Official Full Name
    NHS like 2provided by HGNC
    Primary source
    HGNC:HGNC:33737
    See related
    Ensembl:ENSG00000204131 MIM:301093; AllianceGenome:HGNC:33737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in gall bladder (RPKM 1.5), fat (RPKM 1.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NHSL2 in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (71910845..72153286)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (70344382..70586866)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (71130695..71373136)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein CXorf49-like Neighboring gene chromosome X open reading frame 49 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:71139771-71140271 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:71155233-71155932 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:71176654-71177216 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:71177217-71177778 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:71177779-71178340 Neighboring gene RNA, U6 small nuclear 1078, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:71216621-71217222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29753 Neighboring gene Sharpr-MPRA regulatory region 1584 Neighboring gene ribosomal protein S26 pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:71289659-71290216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29754 Neighboring gene TPT1-like Neighboring gene retrotransposon Gag like 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29755 Neighboring gene RNA, 7SL, cytoplasmic 388, pseudogene Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ44635, MGC169175, MGC169187

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NHS-like protein 2
    Names
    TPT1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029583.2 RefSeqGene

      Range
      5001..247442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001013627.3 → NP_001013649.2  NHS-like protein 2

      Status: VALIDATED

      Source sequence(s)
      AL929401, BX119917
      Consensus CDS
      CCDS87759.1
      UniProtKB/Swiss-Prot
      A0A0J9YY34, B2RN94, Q5HYW2
      Related
      ENSP00000488668.1, ENST00000633930.2
      Conserved Domains (2) summary
      PHA03247
      Location:721 → 955
      PHA03247; large tegument protein UL36; Provisional
      pfam15273
      Location:500 → 756
      NHS; NHS-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      71910845..72153286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442064.1 → XP_047298020.1  NHS-like protein 2 isoform X1

    2. XM_047442065.1 → XP_047298021.1  NHS-like protein 2 isoform X2

    3. XM_047442066.1 → XP_047298022.1  NHS-like protein 2 isoform X3

    4. XM_047442068.1 → XP_047298024.1  NHS-like protein 2 isoform X5

    5. XM_047442070.1 → XP_047298026.1  NHS-like protein 2 isoform X9

    6. XM_011530933.2 → XP_011529235.1  NHS-like protein 2 isoform X8

      Conserved Domains (1) summary
      pfam15273
      Location:479 → 731
      NHS; NHS-like

    7. XM_011530932.2 → XP_011529234.1  NHS-like protein 2 isoform X7

      Conserved Domains (1) summary
      pfam15273
      Location:523 → 775
      NHS; NHS-like

    8. XM_011530934.3 → XP_011529236.1  NHS-like protein 2 isoform X10

      Conserved Domains (1) summary
      pfam15273
      Location:313 → 565
      NHS; NHS-like

    9. XM_047442067.1 → XP_047298023.1  NHS-like protein 2 isoform X4

    10. XM_047442069.1 → XP_047298025.1  NHS-like protein 2 isoform X6

    11. XM_047442071.1 → XP_047298027.1  NHS-like protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A0J9YW69, A0A0J9YY72
      Related
      ENSP00000488715.1, ENST00000631375.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      70344382..70586866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326957.1 → XP_054182932.1  NHS-like protein 2 isoform X1

    2. XM_054326958.1 → XP_054182933.1  NHS-like protein 2 isoform X3

    3. XM_054326960.1 → XP_054182935.1  NHS-like protein 2 isoform X5

    4. XM_054326966.1 → XP_054182941.1  NHS-like protein 2 isoform X9

    5. XM_054326965.1 → XP_054182940.1  NHS-like protein 2 isoform X8

    6. XM_054326963.1 → XP_054182938.1  NHS-like protein 2 isoform X7

    7. XM_054326967.1 → XP_054182942.1  NHS-like protein 2 isoform X10

    8. XM_054326959.1 → XP_054182934.1  NHS-like protein 2 isoform X4

    9. XM_054326971.1 → XP_054182946.1  NHS-like protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A0J9YW69, A0A0J9YY72

    10. XM_054326961.1 → XP_054182936.1  NHS-like protein 2 isoform X12

    11. XM_054326964.1 → XP_054182939.1  NHS-like protein 2 isoform X14

    12. XM_054326969.1 → XP_054182944.1  NHS-like protein 2 isoform X16

      UniProtKB/TrEMBL
      A0A0J9YW69

    13. XM_054326962.1 → XP_054182937.1  NHS-like protein 2 isoform X13

    14. XM_054326968.1 → XP_054182943.1  NHS-like protein 2 isoform X15

      UniProtKB/TrEMBL
      A0A0J9YW69

    15. XM_054326970.1 → XP_054182945.1  NHS-like protein 2 isoform X17

      UniProtKB/TrEMBL
      A0A0J9YW69
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56UQ5.2 GenPept UniProtKB/Swiss-Prot:Q56UQ5
    Q5HYW2.2 GenPept UniProtKB/Swiss-Prot:Q5HYW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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