RPS6KA6 ribosomal protein S6 kinase A6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPS6KA6provided by HGNC
Official Full Name: ribosomal protein S6 kinase A6provided by HGNC
Primary source: HGNC:HGNC:10435
See related: Ensembl:ENSG00000072133 MIM:300303; AllianceGenome:HGNC:10435
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RSK4; RSK-4; p90RSK6; PP90RSK4; S6K-alpha-6
Summary: This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
Expression: Broad expression in thyroid (RPKM 5.0), kidney (RPKM 2.6) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq21.1

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (84058346..84188499, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (82493471..82624675, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (83313354..83443207, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
Title: RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer.
Title: Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer.
High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma.
Title: High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma.
RSK4: a new prognostic factor in glioma.
Title: RSK4: a new prognostic factor in glioma.
Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.
Title: Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.
Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
Title: Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway.
Title: Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway.
E2 signaling may therefore act upstream of RSK4 to promote cancer progression. The results obtained in the current study suggested that RSK4 inhibited breast cancer cell invasiveness and that RSK4 promoter hypomethylation may serve as a novel prognostic marker for patients with breast cancer.
Title: RSK4 inhibits breast cancer cell proliferation and invasion in vitro, and is correlated with estrogen receptor upregulation in breast cancer.
High expression of RSK4 is associated with colorectal cancer.
Title: Effect of RSK4 on biological characteristics of colorectal cancer.
RSK4 constitutes a putative tumor suppressor gene for non-small cell lung carcinoma.
Title: A Pilot Study of RSK4 Expression in Patients with Human Non-Small Cell Lung Carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94074 (e-PCR)
- UniSTS:92950

STS-H82897 (e-PCR)
- UniSTS:43870

D10S16 (e-PCR)
- UniSTS:155756

RH68814 (e-PCR)
- UniSTS:36975

SGC35226 (e-PCR)
- UniSTS:55157

D11S3114 (e-PCR)
- UniSTS:152207

G42197 (e-PCR)
- UniSTS:105115

RPS6KA6_9548 (e-PCR)
- UniSTS:468659

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesoderm development	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IDA Inferred from Direct Assay more info
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-6

Names: 90 kDa ribosomal protein S6 kinase 6; S6K-alpha 6; p90-RSK 6; ribosomal S6 kinase 4; ribosomal protein S6 kinase, 90kDa, polypeptide 6

NP_001317441.1

EC 2.7.11.1

NP_055311.1

EC 2.7.11.1

XP_011529219.1

EC 2.7.11.1

XP_011529221.1

EC 2.7.11.1

XP_011529222.1

EC 2.7.11.1

XP_016884912.1

EC 2.7.11.1

XP_016884913.1

EC 2.7.11.1

XP_016884914.1

EC 2.7.11.1

XP_047297952.1

EC 2.7.11.1

XP_047297953.1

EC 2.7.11.1

XP_054182821.1

EC 2.7.11.1

XP_054182822.1

EC 2.7.11.1

XP_054182823.1

EC 2.7.11.1

XP_054182824.1

EC 2.7.11.1

XP_054182825.1

EC 2.7.11.1

XP_054182826.1

EC 2.7.11.1

XP_054182827.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016340.1 RefSeqGene

Range

4737..134586

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001330512.1 → NP_001317441.1 ribosomal protein S6 kinase alpha-6 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.

Source sequence(s)

AL354653, AL389887, BC143648

Consensus CDS

CCDS83480.1

UniProtKB/TrEMBL

A0AAU7BN28, A0AAU7BN44

Conserved Domains (2) summary

cd05582
Location:77 → 391

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14177
Location:421 → 715

STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
NM_014496.5 → NP_055311.1 ribosomal protein S6 kinase alpha-6 isoform 2

See identical proteins and their annotated locations for NP_055311.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1, but has a distinct N-terminus.

Source sequence(s)

AF184965, AK313240, AL354653, AL389887, BQ448025

Consensus CDS

CCDS14451.1

UniProtKB/Swiss-Prot

B2R854, B7ZL90, Q6FHX2, Q8WX28, Q9H4S6, Q9UK32

UniProtKB/TrEMBL

A0AAU7BN44

Related

ENSP00000262752.2, ENST00000262752.5

Conserved Domains (2) summary

cd05582
Location:77 → 391

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14177
Location:421 → 715

STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

84058346..84188499 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047441997.1 → XP_047297953.1 ribosomal protein S6 kinase alpha-6 isoform X3

UniProtKB/TrEMBL

A0AAU7BMN7, A0AAU7BN44
XM_011530919.3 → XP_011529221.1 ribosomal protein S6 kinase alpha-6 isoform X4

UniProtKB/TrEMBL

A0AAU7BMR9, A0AAU7BMS3

Conserved Domains (4) summary

smart00220
Location:1 → 227

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05582
Location:1 → 288

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14177
Location:318 → 612

STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

pfam00069
Location:323 → 580

Pkinase; Protein kinase domain
XM_017029425.2 → XP_016884914.1 ribosomal protein S6 kinase alpha-6 isoform X1

UniProtKB/TrEMBL

A0AAU7BN44
XM_047441996.1 → XP_047297952.1 ribosomal protein S6 kinase alpha-6 isoform X3

UniProtKB/TrEMBL

A0AAU7BMN7, A0AAU7BN44
XM_011530917.3 → XP_011529219.1 ribosomal protein S6 kinase alpha-6 isoform X2

See identical proteins and their annotated locations for XP_011529219.1

UniProtKB/TrEMBL

A0AAU7BN28, A0AAU7BN44

Conserved Domains (2) summary

cd05582
Location:77 → 391

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14177
Location:421 → 715

STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
XM_017029424.2 → XP_016884913.1 ribosomal protein S6 kinase alpha-6 isoform X1

UniProtKB/TrEMBL

A0AAU7BN44
XM_017029423.2 → XP_016884912.1 ribosomal protein S6 kinase alpha-6 isoform X1

UniProtKB/TrEMBL

A0AAU7BN44

Related

ENSP00000483896.1, ENST00000620340.4
XM_011530920.3 → XP_011529222.1 ribosomal protein S6 kinase alpha-6 isoform X5

UniProtKB/TrEMBL

A0AAU7BMT2, A0AAU7BN70

Conserved Domains (4) summary

smart00220
Location:1 → 209

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14177
Location:300 → 594

STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

pfam00069
Location:305 → 562

Pkinase; Protein kinase domain

cl21453
Location:1 → 270

PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

82493471..82624675 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054326851.1 → XP_054182826.1 ribosomal protein S6 kinase alpha-6 isoform X4

UniProtKB/TrEMBL

A0AAU7BMR9, A0AAU7BMS3
XM_054326848.1 → XP_054182823.1 ribosomal protein S6 kinase alpha-6 isoform X1

UniProtKB/TrEMBL

A0AAU7BN44
XM_054326850.1 → XP_054182825.1 ribosomal protein S6 kinase alpha-6 isoform X3

UniProtKB/TrEMBL

A0AAU7BMN7, A0AAU7BN44
XM_054326849.1 → XP_054182824.1 ribosomal protein S6 kinase alpha-6 isoform X2

UniProtKB/TrEMBL

A0AAU7BN28, A0AAU7BN44
XM_054326847.1 → XP_054182822.1 ribosomal protein S6 kinase alpha-6 isoform X1

UniProtKB/TrEMBL

A0AAU7BN44
XM_054326846.1 → XP_054182821.1 ribosomal protein S6 kinase alpha-6 isoform X1

UniProtKB/TrEMBL

A0AAU7BN44
XM_054326852.1 → XP_054182827.1 ribosomal protein S6 kinase alpha-6 isoform X5

UniProtKB/TrEMBL

A0AAU7BMT2, A0AAU7BN70