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    MRGPRX1 MAS related GPR family member X1 [ Homo sapiens (human) ]

    Gene ID: 259249, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MRGPRX1provided by HGNC
    Official Full Name
    MAS related GPR family member X1provided by HGNC
    Primary source
    HGNC:HGNC:17962
    See related
    Ensembl:ENSG00000170255 MIM:607227; AllianceGenome:HGNC:17962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPCR; MGRG2; MRGX1; SNSR4
    Summary
    Enables transmembrane signaling receptor activity. Involved in cell surface receptor signaling pathway and response to chloroquine. Predicted to be located in cell surface. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MRGPRX1 in Genome Data Viewer
    Location:
    11p15.1; 11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18933499..18939414, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (19031499..19037414, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18955046..18960961, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member X6, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr11:18921836-18922341 Neighboring gene NANOG hESC enhancer GRCh37_chr11:18934386-18934891 Neighboring gene MAS related GPR family member X5, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18943059-18943558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18964603-18965104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18977428-18977928 Neighboring gene NANOG hESC enhancer GRCh37_chr11:18979998-18980547 Neighboring gene MAS related GPR family member X11, pseudogene Neighboring gene MAS related GPR family member X10, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of agonist-induced activation of the human itch receptor MRGPRX1. Gan B, et al. PLoS Biol, 2023 Jun. PMID 37347749, Free PMC Article
    2. BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sanjel B, et al. Sci Rep, 2019 Jul 26. PMID 31350433, Free PMC Article
    3. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Li Z, et al. Proc Natl Acad Sci U S A, 2017 Mar 7. PMID 28223516, Free PMC Article
    4. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Guo L, et al. Nat Commun, 2023 Aug 17. PMID 37591889, Free PMC Article
    5. Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates. Klein A, et al. Elife, 2021 Apr 23. PMID 33891544, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.
      Title: Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.
    2. Mechanism of agonist-induced activation of the human itch receptor MRGPRX1.
      Title: Mechanism of agonist-induced activation of the human itch receptor MRGPRX1.
    3. Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates.
      Title: Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates.
    4. BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus.
      Title: BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus.
    5. Our findings established a novel function for Mrgprc11 in the gut nociceptive innervation
      Title: Mas-related G protein-coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?
    6. Study reports that a cysteine protease mucunain, active component of cowhage (itch-inducing spicules or trichomes that cover the seedpods of the tropical plant Mucuna pruriens) that is routinely used in human studies of histamine-independent itch, activates human MRGPRX1 and MRGPRX2 receptors and induces degranulation of human mast cells.
      Title: Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch.
    7. MRGPRX1 is a promising target for pain inhibition, a humanized mouse model expressing this receptor has been described.
      Title: Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.
    8. Der p1 also induced the release of IL-6 from heterologous cells expressing MRGPRX1. In summary, activation of Mrgprs by the allergen Der p1 may contribute to inflammation.
      Title: Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.
    9. analysis of the functional interactions between MRGPR-X1 and TRPV1
      Title: Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to chloroquine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member X1
    Names
    G protein-coupled receptor MRGX1
    G protein-coupled receptor SNSR3
    MAS-related GPR, member X1
    Mas-related G protein-coupled receptor G2
    sensory neuron-specific G-protein coupled receptor 3/4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393578.1 → NP_001380507.1  mas-related G-protein coupled receptor member X1

      Status: VALIDATED

      Source sequence(s)
      AC023078
      Consensus CDS
      CCDS7846.1
      UniProtKB/Swiss-Prot
      Q4V9L2, Q8TDD8, Q8TDD9, Q96LB2
      UniProtKB/TrEMBL
      B5B0C6, W8W3P5
      Related
      ENSP00000499076.2, ENST00000526914.2
      Conserved Domains (1) summary
      cd15106
      Location:28 → 299
      7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_147199.4 → NP_671732.3  mas-related G-protein coupled receptor member X1

      See identical proteins and their annotated locations for NP_671732.3

      Status: VALIDATED

      Source sequence(s)
      AC023078
      Consensus CDS
      CCDS7846.1
      UniProtKB/Swiss-Prot
      Q4V9L2, Q8TDD8, Q8TDD9, Q96LB2
      UniProtKB/TrEMBL
      B5B0C6, W8W3P5
      Related
      ENSP00000305766.3, ENST00000302797.4
      Conserved Domains (1) summary
      cd15106
      Location:28 → 299
      7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      18933499..18939414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      19031499..19037414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LB2.1 GenPept UniProtKB/Swiss-Prot:Q96LB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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