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    SERPINA10 serpin family A member 10 [ Homo sapiens (human) ]

    Gene ID: 51156, updated on 3-Dec-2024

    Summary

    Official Symbol
    SERPINA10provided by HGNC
    Official Full Name
    serpin family A member 10provided by HGNC
    Primary source
    HGNC:HGNC:15996
    See related
    Ensembl:ENSG00000140093 MIM:605271; AllianceGenome:HGNC:15996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PZI; ZPI
    Summary
    The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]
    Expression
    Restricted expression toward liver (RPKM 44.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SERPINA10 in Genome Data Viewer
    Location:
    14q32.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (94280460..94293268, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88507743..88520553, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94746797..94759605, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94639893-94640455 Neighboring gene protein phosphatase 4 regulatory subunit 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94757989-94758488 Neighboring gene serpin family A member 6 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:94812301-94813500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94828015-94828515 Neighboring gene serpin family A member 2 (gene/pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in regulation of acrosome reaction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein Z-dependent protease inhibitor
    Names
    PZ-dependent protease inhibitor
    Protein-Z dependent proteinase inhibitor
    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
    serpin A10
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021202.2 RefSeqGene

      Range
      4992..17800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_576

    mRNA and Protein(s)

    1. NM_001100607.3NP_001094077.1  protein Z-dependent protease inhibitor precursor

      See identical proteins and their annotated locations for NP_001094077.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF181467, AL117259, BC022261
      Consensus CDS
      CCDS9923.1
      UniProtKB/Swiss-Prot
      A5Z2A5, Q6UWX9, Q86U20, Q9UK55
      UniProtKB/TrEMBL
      B2RBZ5
      Related
      ENSP00000261994.4, ENST00000261994.9
      Conserved Domains (1) summary
      cd02055
      Location:74438
      PZI; Protein Z-dependent protease inhibitor (ZPI) is a member of the serpin superfamily of proteinase inhibitors (clade A10). ZPI inhibits coagulation factor Xa , dependent on protein Z (PZ), a vitamin K-dependent plasma protein. ZPI also inhibits factor XIa ...
    2. NM_016186.3NP_057270.1  protein Z-dependent protease inhibitor precursor

      See identical proteins and their annotated locations for NP_057270.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF181467, AI174900, AL117259
      Consensus CDS
      CCDS9923.1
      UniProtKB/Swiss-Prot
      A5Z2A5, Q6UWX9, Q86U20, Q9UK55
      UniProtKB/TrEMBL
      B2RBZ5
      Related
      ENSP00000376809.1, ENST00000393096.5
      Conserved Domains (1) summary
      cd02055
      Location:74438
      PZI; Protein Z-dependent protease inhibitor (ZPI) is a member of the serpin superfamily of proteinase inhibitors (clade A10). ZPI inhibits coagulation factor Xa , dependent on protein Z (PZ), a vitamin K-dependent plasma protein. ZPI also inhibits factor XIa ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      94280460..94293268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021353.2XP_016876842.1  protein Z-dependent protease inhibitor isoform X1

      UniProtKB/TrEMBL
      B2RBZ5, G3V2W1
      Related
      ENSP00000450896.1, ENST00000554723.5
      Conserved Domains (1) summary
      cd02055
      Location:114478
      PZI; Protein Z-dependent protease inhibitor (ZPI) is a member of the serpin superfamily of proteinase inhibitors (clade A10). ZPI inhibits coagulation factor Xa , dependent on protein Z (PZ), a vitamin K-dependent plasma protein. ZPI also inhibits factor XIa ...
    2. XM_005267733.6XP_005267790.1  protein Z-dependent protease inhibitor isoform X2

      See identical proteins and their annotated locations for XP_005267790.1

      UniProtKB/Swiss-Prot
      A5Z2A5, Q6UWX9, Q86U20, Q9UK55
      UniProtKB/TrEMBL
      B2RBZ5
      Conserved Domains (1) summary
      cd02055
      Location:74438
      PZI; Protein Z-dependent protease inhibitor (ZPI) is a member of the serpin superfamily of proteinase inhibitors (clade A10). ZPI inhibits coagulation factor Xa , dependent on protein Z (PZ), a vitamin K-dependent plasma protein. ZPI also inhibits factor XIa ...

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1395022..1407830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328978.1XP_054184953.1  protein Z-dependent protease inhibitor isoform X1

      UniProtKB/TrEMBL
      B2RBZ5, G3V2W1
    2. XM_054328979.1XP_054184954.1  protein Z-dependent protease inhibitor isoform X2

      UniProtKB/Swiss-Prot
      A5Z2A5, Q6UWX9, Q86U20, Q9UK55
      UniProtKB/TrEMBL
      B2RBZ5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      88507743..88520553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376169.1XP_054232144.1  protein Z-dependent protease inhibitor isoform X1

      UniProtKB/TrEMBL
      B2RBZ5
    2. XM_054376170.1XP_054232145.1  protein Z-dependent protease inhibitor isoform X2

      UniProtKB/TrEMBL
      B2RBZ5