MCTS1 MCTS1 re-initiation and release factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: MCTS1provided by HGNC
Official Full Name: MCTS1 re-initiation and release factorprovided by HGNC
Primary source: HGNC:HGNC:23357
See related: Ensembl:ENSG00000232119 MIM:300587; AllianceGenome:HGNC:23357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MCT1; MCT-1; IMD118
Summary: Enables RNA cap binding activity; ribosomal small subunit binding activity; and translation factor activity, non-nucleic acid binding. Involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Is active in cytoplasm. Implicated in primary immunodeficiency disease. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lymph node (RPKM 3.6), brain (RPKM 3.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (120604101..120621159)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (118979555..118996612)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (119737956..119755014)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human MCTS1-dependent translation of JAK2 is essential for IFN-gamma immunity to mycobacteria.
Title: Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria.
MCTS1 enhances the proliferation of laryngeal squamous cell carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination.
Title: MCTS1 enhances the proliferation of laryngeal squamous cell carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination.
MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability.
Title: MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability.
Prognostic value of malignant T cell-amplified sequence 1 in head and neck squamous cell carcinoma.
Title: Prognostic value of malignant T cell-amplified sequence 1 in head and neck squamous cell carcinoma.
MCT1 expression is independently related to shorter cancer-specific survival in clear cell renal cell carcinoma.
Title: MCT1 expression is independently related to shorter cancer-specific survival in clear cell renal cell carcinoma.
These results suggest MCT-1/miR-34a/IL-6/IL-6R axis is responsible for MCT-1-mediated effects on non-small cell lung cance cell stemness.
Title: Multiple Copies in T-Cell Malignancy 1 (MCT-1) Promotes the Stemness of Non-Small Cell Lung Cancer Cells via Activating Interleukin-6 (IL-6) Signaling through Suppressing MiR-34a Expression.
High MCT-1 expression is associated with M2-like polarization and triple-negative breast cancer cell invasion.
Title: MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer.
Present the crystal structure of MCTS1 bound to a fragment of DENR. Based on this structure, we identify and experimentally validate that DENR residues Glu42, Tyr43, and Tyr46 are important for MCTS1 binding and that MCTS1 residue Phe104 is important for tRNA binding. Mutation of these residues reveals that DENR-MCTS1 dimerization and tRNA binding are both necessary for DENR and MCTS1 to promote translation reinitiation.
Title: DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation.
findings elucidate further the mechanism of regulation of DENR-MCT-1 activities in unconventional translation initiation, reinitiation, and recycling.
Title: Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation.
PKC inhibitor sotrastaurin induced cell apoptosis and cell cycle arrest in DLBCL cells potentially through regulating the expression of MCT-1
Title: PKC inhibition of sotrastaurin has antitumor activity in diffuse large B-cell lymphoma via regulating the expression of MCT-1.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Immunodeficiency 118 MedGen: C5882665 OMIM: 301115 GeneReviews: Not available	not available

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

GDB:434012 (e-PCR)
- UniSTS:157204

PMC156606P3 (e-PCR)
- UniSTS:271410

D8S2279 (e-PCR)
- UniSTS:473907

RH75489 (e-PCR)
- UniSTS:84533

sY3084 (e-PCR)
- UniSTS:515126

DXS8324 (e-PCR)
- UniSTS:14937

D1S1423 (e-PCR)
- UniSTS:149619

GDB:335751 (e-PCR)
- UniSTS:156601

D11S3316 (e-PCR)
- UniSTS:152558

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA cap binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal small subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables translation factor activity, non-nucleic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in IRES-dependent viral translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of translation preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in ribosome disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosome disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation reinitiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: malignant T-cell-amplified sequence 1

Names: malignant T-cell amplified sequence 1; multiple copies T-cell malignancies; multiple copies in T-cell lymphoma-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001137554.2 → NP_001131026.1 malignant T-cell-amplified sequence 1 isoform 2

See identical proteins and their annotated locations for NP_001131026.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AA375691, AC011890, AK294834, AW957695, BM671542

Consensus CDS

CCDS48160.1

UniProtKB/Swiss-Prot

Q9ULC4

Related

ENSP00000360365.3, ENST00000371315.3

Conserved Domains (2) summary

cd11609
Location:5 → 81

MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins

cd21155
Location:81 → 176

PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins
NM_014060.3 → NP_054779.1 malignant T-cell-amplified sequence 1 isoform 1

See identical proteins and their annotated locations for NP_054779.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).

Source sequence(s)

AC011890, BC001013, BM671542, BP226595

Consensus CDS

CCDS14601.1

UniProtKB/Swiss-Prot

B4DGY2, Q502X6, Q9ULC4

Related

ENSP00000360367.5, ENST00000371317.10

Conserved Domains (2) summary

cd11609
Location:4 → 80

MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins

cd21155
Location:80 → 175

PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins