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    Protein phosphatase 2C family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826705, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Protein phosphatase 2C family protein
    Primary source
    TAIR:AT4G11040
    Locus tag
    AT4G11040
    See related
    Araport:AT4G11040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    RDO5; REDUCED DORMANCY 5; T22B4.20; T22B4_20
    Summary
    Encodes a nuclear localized protein with sequence similarity to PP2C phosphatases that is involved in seed dormancy. Loss of function mutations have reduced seed dormancy but does not act through ABA or DOG1 pathways.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (6745100..6746944)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene AMP-dependent synthetase and ligase family protein Neighboring gene glycosyl hydrolase 9C3 Neighboring gene mitochondrially targeted single-stranded DNA binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arabidopsis Dormancy. Xiang Y, et al. Plant Physiol, 2016 Aug. PMID 27288362, Free PMC Article
    2. The IBO germination quantitative trait locus encodes a phosphatase 2C-related variant with a nonsynonymous amino acid change that interferes with abscisic acid signaling. Amiguet-Vercher A, et al. New Phytol, 2015 Feb. PMID 25490966
    3. Reduced Dormancy5 encodes a protein phosphatase 2C that is required for seed dormancy in Arabidopsis. Xiang Y, et al. Plant Cell, 2014 Nov. PMID 25415980, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RDO5 acts as a pseudophosphatase that inhibits dephosphorylation during seed imbibition.
      Title: Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arabidopsis Dormancy.
    2. APUM9 reduces seed dormancy. Interestingly, reduction of APUM transcripts by RNA interference complemented the reduced dormancy phenotype of rdo5, indicating that RDO5 functions by suppressing APUM transcript levels.
      Title: Reduced Dormancy5 encodes a protein phosphatase 2C that is required for seed dormancy in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001203771.1
    NM_117174.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables pseudophosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of seed dormancy process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed dormancy process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Protein phosphatase 2C family protein
    NP_001190700.1
    • Protein phosphatase 2C family protein; FUNCTIONS IN: protein serine/threonine phosphatase activity; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C (InterPro:IPR015655).
    NP_192842.1
    • Protein phosphatase 2C family protein; FUNCTIONS IN: protein serine/threonine phosphatase activity, catalytic activity; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: highly ABA-induced PP2C gene 3 (TAIR:AT2G29380.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      6745100..6746944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203771.1 → NP_001190700.1  Protein phosphatase 2C family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190700.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JN82
      Conserved Domains (1) summary
      smart00332
      Location:79 → 197
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

    2. NM_117174.3 → NP_192842.1  Protein phosphatase 2C family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192842.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81613, Q9T010
      UniProtKB/TrEMBL
      A0A178UX72, A0A5S9XR78
      Conserved Domains (1) summary
      smart00332
      Location:79 → 287
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9T010.1

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