TYK2 tyrosine kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TYK2provided by HGNC
Official Full Name: tyrosine kinase 2provided by HGNC
Primary source: HGNC:HGNC:12440
See related: Ensembl:ENSG00000105397 MIM:176941; AllianceGenome:HGNC:12440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JTK1; IMD35
Summary: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in spleen (RPKM 21.6), bone marrow (RPKM 20.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (10350533..10380572, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (10476657..10506988, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (10461209..10491248, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.
Title: TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.
Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population.
Title: Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population.
Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.
Title: Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.
Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.
Title: Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.
Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
Title: Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.
Title: The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.
TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.
Title: TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.
Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.
Title: Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.
Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
Title: Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.
Title: Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Immunodeficiency 35 MedGen: C1969086 OMIM: 611521 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-7649 (e-PCR)
- UniSTS:51764

STS-X54637 (e-PCR)
- UniSTS:53951

RH70299 (e-PCR)
- UniSTS:77020

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables growth hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IC Inferred by Curator more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables type 1 angiotensin receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to virus	NAS Non-traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in interleukin-10-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-12-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-23-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NK T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NK T cell proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 17 type immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of interleukin-17 production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of natural killer cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type I interferon-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in type I interferon-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in type II interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type III interferon-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of plasma membrane	IC Inferred by Curator more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in extrinsic component of cytoplasmic side of plasma membrane	IC Inferred by Curator more info	PubMed
is_active_in extrinsic component of plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of interleukin-12 receptor complex	NAS Non-traceable Author Statement more info	PubMed
part_of interleukin-23 receptor complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: non-receptor tyrosine-protein kinase TYK2

NP_001372126.1

EC 2.7.10.2

NP_001372127.1

EC 2.7.10.2

NP_001372128.1

EC 2.7.10.2

NP_001372129.1

EC 2.7.10.2

NP_001372130.1

EC 2.7.10.2

NP_001372131.1

EC 2.7.10.2

NP_001372132.1

EC 2.7.10.2

NP_001372133.1

EC 2.7.10.2

NP_001372134.1

EC 2.7.10.2

NP_001372135.1

EC 2.7.10.2

NP_001372136.1

EC 2.7.10.2

NP_001393390.1

EC 2.7.10.2

NP_003322.3

EC 2.7.10.2

XP_011526548.1

EC 2.7.10.2

XP_011526549.1

EC 2.7.10.2

XP_011526551.1

EC 2.7.10.2

XP_047295260.1

EC 2.7.10.2

XP_047295261.1

EC 2.7.10.2

XP_047295262.1

EC 2.7.10.2

XP_047295263.1

EC 2.7.10.2

XP_054177893.1

EC 2.7.10.2

XP_054177894.1

EC 2.7.10.2

XP_054177895.1

EC 2.7.10.2

XP_054177896.1

EC 2.7.10.2

XP_054177897.1

EC 2.7.10.2

XP_054177898.1

EC 2.7.10.2

XP_054177899.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007872.1 RefSeqGene

Range

5001..35045

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_121

mRNA and Protein(s)

NM_001385197.1 → NP_001372126.1 non-receptor tyrosine-protein kinase TYK2 isoform 3

Status: REVIEWED

Source sequence(s)

AC011557

Consensus CDS

CCDS92513.1

UniProtKB/TrEMBL

A0A8E7DA23, H0YE24

Related

ENSP00000434831.2, ENST00000525976.6

Conserved Domains (6) summary

cd05076
Location:589 → 867

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam17887
Location:285 → 432

Jak1_Phl; Jak1 pleckstrin homology-like domain

pfam18377
Location:143 → 266

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:437 → 534

SH2; Src homology 2 (SH2) domain

cl21453
Location:892 → 1137

PKc_like; Protein Kinases, catalytic domain
NM_001385198.1 → NP_001372127.1 non-receptor tyrosine-protein kinase TYK2 isoform 4

Status: REVIEWED

Source sequence(s)

AC011557

UniProtKB/TrEMBL

A0A8V8TPJ0

Conserved Domains (6) summary

cd05076
Location:589 → 867

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam17887
Location:285 → 432

Jak1_Phl; Jak1 pleckstrin homology-like domain

pfam18377
Location:143 → 266

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:437 → 534

SH2; Src homology 2 (SH2) domain

cl21453
Location:892 → 1124

PKc_like; Protein Kinases, catalytic domain
NM_001385199.1 → NP_001372128.1 non-receptor tyrosine-protein kinase TYK2 isoform 5

Status: REVIEWED

Source sequence(s)

AC011557

UniProtKB/TrEMBL

A0A8E7DA23

Conserved Domains (6) summary

cd05080
Location:830 → 1112

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam17887
Location:285 → 432

Jak1_Phl; Jak1 pleckstrin homology-like domain

pfam18377
Location:143 → 266

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:437 → 534

SH2; Src homology 2 (SH2) domain

cl21453
Location:586 → 805

PKc_like; Protein Kinases, catalytic domain
NM_001385200.1 → NP_001372129.1 non-receptor tyrosine-protein kinase TYK2 isoform 6

Status: REVIEWED

Source sequence(s)

AC011557

UniProtKB/TrEMBL

A0A8E7DA23

Conserved Domains (6) summary

cd05076
Location:589 → 866

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

cd05080
Location:891 → 1173

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam17887
Location:285 → 432

Jak1_Phl; Jak1 pleckstrin homology-like domain

pfam18377
Location:143 → 266

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:437 → 534

SH2; Src homology 2 (SH2) domain
NM_001385201.1 → NP_001372130.1 non-receptor tyrosine-protein kinase TYK2 isoform 7

Status: REVIEWED

Source sequence(s)

AC011557

UniProtKB/TrEMBL

A0A8E7DA23

Conserved Domains (6) summary

cd05076
Location:523 → 801

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

cd05080
Location:826 → 1108

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam18377
Location:143 → 266

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:371 → 468

SH2; Src homology 2 (SH2) domain

cl17171
Location:270 → 371

PH-like; Pleckstrin homology-like domain
NM_001385202.1 → NP_001372131.1 non-receptor tyrosine-protein kinase TYK2 isoform 8

Status: REVIEWED

Source sequence(s)

AC011557

UniProtKB/TrEMBL

A0A8E7DA23

Conserved Domains (6) summary

cd05080
Location:864 → 1146

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam17887
Location:285 → 432

Jak1_Phl; Jak1 pleckstrin homology-like domain

pfam18377
Location:143 → 266

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:437 → 534

SH2; Src homology 2 (SH2) domain

cl21453
Location:589 → 839

PKc_like; Protein Kinases, catalytic domain
NM_001385203.1 → NP_001372132.1 non-receptor tyrosine-protein kinase TYK2 isoform 9

Status: REVIEWED

Source sequence(s)

AC011557

UniProtKB/TrEMBL

A0A8E7DA23

Conserved Domains (6) summary

cd05076
Location:589 → 867

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

cd05080
Location:919 → 1201

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam17887
Location:285 → 432

Jak1_Phl; Jak1 pleckstrin homology-like domain

pfam18377
Location:143 → 266

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:437 → 534

SH2; Src homology 2 (SH2) domain
NM_001385204.1 → NP_001372133.1 non-receptor tyrosine-protein kinase TYK2 isoform 1

Status: REVIEWED

Source sequence(s)

AC011557

UniProtKB/TrEMBL

A0A8E7DA23

Related

ENST00000529370.6

Conserved Domains (6) summary

cd05080
Location:962 → 1244

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam17887
Location:285 → 432

Jak1_Phl; Jak1 pleckstrin homology-like domain

pfam18377
Location:143 → 266

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:437 → 534

SH2; Src homology 2 (SH2) domain

cl21453
Location:589 → 937

PKc_like; Protein Kinases, catalytic domain
NM_001385205.1 → NP_001372134.1 non-receptor tyrosine-protein kinase TYK2 isoform 10

Status: REVIEWED

Source sequence(s)

AC011557

UniProtKB/TrEMBL

A0A8E7DA23

Conserved Domains (6) summary

cd05076
Location:559 → 837

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

cd05080
Location:862 → 1144

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam17887
Location:255 → 402

Jak1_Phl; Jak1 pleckstrin homology-like domain

pfam18377
Location:143 → 236

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:407 → 504

SH2; Src homology 2 (SH2) domain
NM_001385206.1 → NP_001372135.1 non-receptor tyrosine-protein kinase TYK2 isoform 11

Status: REVIEWED

Source sequence(s)

AC011557

UniProtKB/TrEMBL

A0A8E7DA23

Conserved Domains (6) summary

cd05076
Location:547 → 825

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

cd05080
Location:850 → 1132

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam17887
Location:285 → 432

Jak1_Phl; Jak1 pleckstrin homology-like domain

pfam18377
Location:143 → 266

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:437 → 490

SH2; Src homology 2 (SH2) domain
NM_001385207.1 → NP_001372136.1 non-receptor tyrosine-protein kinase TYK2 isoform 12

Status: REVIEWED

Source sequence(s)

AC011557

UniProtKB/TrEMBL

A0A8E7DA23

Conserved Domains (6) summary

cd05080
Location:886 → 1168

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam17887
Location:285 → 432

Jak1_Phl; Jak1 pleckstrin homology-like domain

pfam18377
Location:143 → 266

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:28 → 125

FERM_F1; FERM F1 ubiquitin-like domain

cl15255
Location:437 → 534

SH2; Src homology 2 (SH2) domain

cl21453
Location:584 → 861

PKc_like; Protein Kinases, catalytic domain
NM_001406461.1 → NP_001393390.1 non-receptor tyrosine-protein kinase TYK2 isoform 2

Status: REVIEWED

Source sequence(s)

AC011557

Consensus CDS

CCDS12236.1

UniProtKB/Swiss-Prot

P29597, Q6QB10, Q96CH0

Related

ENSP00000436175.2, ENST00000531836.7
NM_003331.5 → NP_003322.3 non-receptor tyrosine-protein kinase TYK2 isoform 2

See identical proteins and their annotated locations for NP_003322.3

Status: REVIEWED

Source sequence(s)

AK308360, BC014243, DA864169

Consensus CDS

CCDS12236.1

UniProtKB/Swiss-Prot

P29597, Q6QB10, Q96CH0

UniProtKB/TrEMBL

A0A8E7DA23

Related

ENSP00000431885.1, ENST00000525621.6

Conserved Domains (7) summary

smart00219
Location:897 → 1169

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:28 → 273

B41; Band 4.1 homologues

cd05076
Location:589 → 867

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

cd05080
Location:892 → 1174

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam07714
Location:589 → 866

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:437 → 534

SH2; Src homology 2 (SH2) domain

cl17171
Location:270 → 437

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

10350533..10380572 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528246.4 → XP_011526548.1 non-receptor tyrosine-protein kinase TYK2 isoform X2

See identical proteins and their annotated locations for XP_011526548.1

UniProtKB/TrEMBL

E9PM19

Conserved Domains (7) summary

smart00219
Location:798 → 1070

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:2 → 174

B41; Band 4.1 homologues

cd05076
Location:490 → 768

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

cd05080
Location:793 → 1075

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam07714
Location:490 → 767

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:338 → 435

SH2; Src homology 2 (SH2) domain

cl17171
Location:171 → 338

PH-like; Pleckstrin homology-like domain
XM_011528247.2 → XP_011526549.1 non-receptor tyrosine-protein kinase TYK2 isoform X2

See identical proteins and their annotated locations for XP_011526549.1

UniProtKB/TrEMBL

E9PM19

Related

ENSP00000433203.1, ENST00000524462.5

Conserved Domains (7) summary

smart00219
Location:798 → 1070

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:2 → 174

B41; Band 4.1 homologues

cd05076
Location:490 → 768

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

cd05080
Location:793 → 1075

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam07714
Location:490 → 767

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:338 → 435

SH2; Src homology 2 (SH2) domain

cl17171
Location:171 → 338

PH-like; Pleckstrin homology-like domain
XM_011528249.3 → XP_011526551.1 non-receptor tyrosine-protein kinase TYK2 isoform X4

Conserved Domains (5) summary

smart00219
Location:455 → 727

TyrKc; Tyrosine kinase, catalytic domain

cd05076
Location:147 → 425

PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

cd05080
Location:450 → 732

PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2

pfam07714
Location:147 → 424

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:15 → 92

SH2; Src homology 2 (SH2) domain
XM_047439304.1 → XP_047295260.1 non-receptor tyrosine-protein kinase TYK2 isoform X1
XM_047439305.1 → XP_047295261.1 non-receptor tyrosine-protein kinase TYK2 isoform X3

UniProtKB/TrEMBL

A0A8V8TN50

Related

ENSP00000514329.1, ENST00000699358.1
XM_047439306.1 → XP_047295262.1 non-receptor tyrosine-protein kinase TYK2 isoform X5

UniProtKB/TrEMBL

H0YCT7

Related

ENSP00000432320.2, ENST00000533334.2
XM_047439307.1 → XP_047295263.1 non-receptor tyrosine-protein kinase TYK2 isoform X6

UniProtKB/TrEMBL

A0A8V8TPX5

Related

ENSP00000514328.1, ENST00000699355.1

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

10476657..10506988 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321919.1 → XP_054177894.1 non-receptor tyrosine-protein kinase TYK2 isoform X2
XM_054321920.1 → XP_054177895.1 non-receptor tyrosine-protein kinase TYK2 isoform X2
XM_054321922.1 → XP_054177897.1 non-receptor tyrosine-protein kinase TYK2 isoform X4
XM_054321918.1 → XP_054177893.1 non-receptor tyrosine-protein kinase TYK2 isoform X1
XM_054321921.1 → XP_054177896.1 non-receptor tyrosine-protein kinase TYK2 isoform X3
XM_054321923.1 → XP_054177898.1 non-receptor tyrosine-protein kinase TYK2 isoform X5
XM_054321924.1 → XP_054177899.1 non-receptor tyrosine-protein kinase TYK2 isoform X6