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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_009633.1 RefSeqGene
- Range
-
5001..78391
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_110
mRNA and Protein(s)
-
NM_001127698.2 → NP_001121170.1 serine protease inhibitor Kazal-type 5 isoform a preproprotein
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, also known as SPINK5l) represents the longest transcript and encodes the longest isoform (a, also known as the LEKTIl or long isoform).
- Source sequence(s)
-
AC116334, AI341060, AK025197, AK307588, AK307648, BI256857, DQ149928, DR421881
- Consensus CDS
-
CCDS47300.1
- UniProtKB/TrEMBL
-
B4DWS3
- Related
- ENSP00000352936.3, ENST00000359874.7
- Conserved Domains (3) summary
-
- smart00280
Location:787 → 827
- KAZAL; Kazal type serine protease inhibitors
- cd01327
Location:1032 → 1076
- KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...
- cl00097
Location:310 → 346
- KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
-
NM_001127699.2 → NP_001121171.1 serine protease inhibitor Kazal-type 5 isoform c preproprotein
Status: REVIEWED
- Description
- Transcript Variant: This variant (3, also known as SPINK5sh) differs in the 3' UTR and lacks several exons in the 3' coding region, compared to variant 1. The resulting protein (isoform c, also known as the LEKTIsh or short isoform) has a distinct C-terminus and is shorter than isoform a.
- Source sequence(s)
-
AC008722, AK025197, AK307588, AK307648, DQ149929
- Consensus CDS
-
CCDS47301.1
- UniProtKB/TrEMBL
-
B4DWS3
- Related
- ENSP00000381472.1, ENST00000398454.5
- Conserved Domains (3) summary
-
- smart00280
Location:787 → 827
- KAZAL; Kazal type serine protease inhibitors
- cd01327
Location:107 → 151
- KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...
- pfam07648
Location:311 → 348
- Kazal_2; Kazal-type serine protease inhibitor domain
-
NM_006846.4 → NP_006837.2 serine protease inhibitor Kazal-type 5 isoform b preproprotein
See identical proteins and their annotated locations for NP_006837.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2, also known as SPINK5f-l) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform b, also known as the LEKTIf-l isoform), compared to isoform a.
- Source sequence(s)
-
AC116334, AI341060, AK025197, AK307588, AK307648, DQ149927, DR421881
- Consensus CDS
-
CCDS43382.1
- UniProtKB/Swiss-Prot
- A8MYE8, B7WPB7, D6REN5, O75770, Q3LX95, Q3LX96, Q3LX97, Q96PP2, Q96PP3, Q9NQ38
- UniProtKB/TrEMBL
-
B4DWS3
- Related
- ENSP00000256084.7, ENST00000256084.8
- Conserved Domains (3) summary
-
- smart00280
Location:787 → 827
- KAZAL; Kazal type serine protease inhibitors
- cd01327
Location:1002 → 1046
- KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...
- cl00097
Location:310 → 348
- KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000005.10 Reference GRCh38.p14 Primary Assembly
- Range
-
148063980..148137382
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047416662.1 → XP_047272618.1 serine protease inhibitor Kazal-type 5 isoform X1
- UniProtKB/TrEMBL
-
B4DWS3
-
XM_011537551.3 → XP_011535853.1 serine protease inhibitor Kazal-type 5 isoform X2
- Conserved Domains (3) summary
-
- smart00280
Location:759 → 799
- KAZAL; Kazal type serine protease inhibitors
- cd01327
Location:1004 → 1048
- KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...
- pfam07648
Location:283 → 320
- Kazal_2; Kazal-type serine protease inhibitor domain
-
XM_047416663.1 → XP_047272619.1 serine protease inhibitor Kazal-type 5 isoform X3
Alternate T2T-CHM13v2.0
Genomic
-
NC_060929.1 Alternate T2T-CHM13v2.0
- Range
-
148599687..148673088
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054351498.1 → XP_054207473.1 serine protease inhibitor Kazal-type 5 isoform X2