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    KIF22 kinesin family member 22 [ Homo sapiens (human) ]

    Gene ID: 3835, updated on 9-Dec-2024

    Summary

    Official Symbol
    KIF22provided by HGNC
    Official Full Name
    kinesin family member 22provided by HGNC
    Primary source
    HGNC:HGNC:6391
    See related
    Ensembl:ENSG00000079616 MIM:603213; AllianceGenome:HGNC:6391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KID; OBP; KNSL4; OBP-1; OBP-2; SEMDJL2; A-328A3.2
    Summary
    The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Broad expression in bone marrow (RPKM 24.9), testis (RPKM 13.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KIF22 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (29790751..29805385)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30072908..30087551)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29802072..29816706)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903675 Neighboring gene zymogen granule protein 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10674 Neighboring gene uncharacterized LOC105371167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10677 Neighboring gene MYC associated zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7339 Neighboring gene MVP divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29826183-29826812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10679 Neighboring gene proline rich transmembrane protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev KID is hypothesized to be a human breast cancer variant of Rev/Rex effector binding protein (REBP), a nuclear protein that binds HIV-1 Rev, co-localizes with Rev in the nucleoplasm and nuclear periphery of cells, and enhances Rev-dependent mRNA expression PubMed
    Vpr vpr HIV-1 Vpr upregulates KIF22 in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF22
    Names
    kinesin-like DNA-binding protein pseudogene
    kinesin-like protein 4
    oriP binding protein
    origin of plasmid DNA replication-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032055.1 RefSeqGene

      Range
      5039..19672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256269.2NP_001243198.1  kinesin-like protein KIF22 isoform 2

      See identical proteins and their annotated locations for NP_001243198.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus than isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK223431, AK316389, BC028155, DC370294
      Consensus CDS
      CCDS58444.1
      UniProtKB/TrEMBL
      B7Z9T5
      Related
      ENSP00000509977.1, ENST00000690258.1
      Conserved Domains (3) summary
      smart00129
      Location:2307
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01376
      Location:1298
      KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
      pfam12836
      Location:528578
      HHH_3; Helix-hairpin-helix motif
    2. NM_001256270.1NP_001243199.1  kinesin-like protein KIF22 isoform 2

      See identical proteins and their annotated locations for NP_001243199.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus than isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC009133, AK223431, AK316050, BC004352, BC028155
      Consensus CDS
      CCDS58444.1
      UniProtKB/TrEMBL
      B7Z9T5
      Related
      ENSP00000454957.1, ENST00000561482.6
      Conserved Domains (3) summary
      smart00129
      Location:2307
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01376
      Location:1298
      KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
      pfam12836
      Location:528578
      HHH_3; Helix-hairpin-helix motif
    3. NM_007317.3NP_015556.1  kinesin-like protein KIF22 isoform 1

      See identical proteins and their annotated locations for NP_015556.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC009133
      Consensus CDS
      CCDS10653.1
      UniProtKB/Swiss-Prot
      B2R5M0, B7Z265, O60845, O94814, Q14807, Q53F58, Q9BT46
      UniProtKB/TrEMBL
      H3BRB3
      Related
      ENSP00000160827.5, ENST00000160827.9
      Conserved Domains (2) summary
      cd01376
      Location:43366
      KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
      cl28530
      Location:596646
      ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      29790751..29805385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434094.1XP_047290050.1  kinesin-like protein KIF22 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KTF7, A0A8I5QL17
      Related
      ENSP00000509109.1, ENST00000689089.1
    2. XM_047434095.1XP_047290051.1  kinesin-like protein KIF22 isoform X2

      UniProtKB/TrEMBL
      A0A8I5QJC5
      Related
      ENSP00000509077.1, ENST00000685401.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30072908..30087551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380309.1XP_054236284.1  kinesin-like protein KIF22 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KTF7, A0A8I5QL17
    2. XM_054380310.1XP_054236285.1  kinesin-like protein KIF22 isoform X2

      UniProtKB/TrEMBL
      A0A8I5QJC5