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Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500261, updated on 27-Nov-2024

Summary

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Official Symbol: Magi1provided by RGD
Official Full Name: membrane associated guanylate kinase, WW and PDZ domain containing 1provided by RGD
Primary source: RGD:1586025
See related: EnsemblRapid:ENSRNOG00000022060 AllianceGenome:RGD:1586025
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BAP-1; Baiap1; MAGI-1
Summary: Predicted to enable alpha-actinin binding activity. Predicted to be involved in endothelial cell morphogenesis; positive regulation of cell-cell adhesion; and signal transduction. Predicted to be located in several cellular components, including adherens junction; nuclear lumen; and plasma membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 115.8), Lung (RPKM 114.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Magi1 in Genome Data Viewer

Location:: 4q34

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (127762590..128368228, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (126205663..126811354, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (125684816..126300013, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.
Title: MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.
Dorsal root ganglion (DRG)-specific knockdown of Magi-1 attenuated thermal nociception and acute inflammatory pain and NaV1.8 protein expression. Magi-1 bound to Slack potassium channels, macrocomplexing with NaV1.8 channels.Magi-1 is an essential scaffold for ion transport in DRG neurons and a central player in pain.Magi-1 is expressed in small- and medium-sized DRG neurons, their axonal tracts, and nodes of Ranvier.
Title: Magi-1 scaffolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and pain.
MAGI-1 was expressed in Purkinje cells, in hypocampal neurons in CA1 region, in the glomerulus region of olfactory bulb, and at the dorsal root entry zone in embryonic rat spinal cord
Title: Biochemical and morphological characterization of MAGI-1 in neuronal tissue.
These results demonstrate that the phosphorylation-dependent scaffolding of the basolateral K(+) channels by MAGI-1a-long participates in the renal regulation of the fluid and electrolyte homeostasis.
Title: MAGI-1a functions as a scaffolding protein for the distal renal tubular basolateral K+ channels.
These data suggest that MAGI-1 regulates surface expression of GLT-1 and the level of glutamate in the hippocampus
Title: Regulation of glutamate transporter GLT-1 by MAGI-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048387 (e-PCR)
- UniSTS:109585

D4Mgh18 (e-PCR)
- UniSTS:119589

RH128955 (e-PCR)
- UniSTS:212263

BG380331 (e-PCR)
- UniSTS:249643

RH132066 (e-PCR)
- UniSTS:215349

D4Rat105 (e-PCR), detects polymorphism
- UniSTS:227704

BB468191 (e-PCR)
- UniSTS:208002

AU048577 (e-PCR)
- UniSTS:145027

D6Mit178 (e-PCR), detects polymorphism
- UniSTS:130722

BE112829 (e-PCR)
- UniSTS:246199

BF395930 (e-PCR)
- UniSTS:245453

AW252028 (e-PCR)
- UniSTS:260820

BI278044 (e-PCR)
- UniSTS:244197

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables alpha-actinin binding	IEA Inferred from Electronic Annotation more info
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endothelial cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Names: BAI1-associated protein 1; membrane-associated guanylate kinase inverted 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030045.2 → NP_001025216.2 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004
NM_001401825.1 → NP_001388754.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

Related

ENSRNOP00000100639.1, ENSRNOT00000133320.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

127762590..128368228 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236927.5 → XP_006236989.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

A0A0G2JZE4

Related

ENSRNOP00000065881.4, ENSRNOT00000071315.5

Conserved Domains (6) summary

smart00228
Location:1151 → 1233

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:303 → 332

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:995 → 1090

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:361 → 390

WW; WW domain

pfam16666
Location:721 → 804

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039108183.2 → XP_038964111.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

UniProtKB/TrEMBL

A0A8I6ABL7

Related

ENSRNOP00000033083.8, ENSRNOT00000037848.8

Conserved Domains (6) summary

smart00456
Location:361 → 392

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1151 → 1233

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:303 → 332

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:995 → 1090

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16666
Location:723 → 805

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039108192.2 → XP_038964120.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X40

UniProtKB/TrEMBL

A0A8I5Y118

Conserved Domains (6) summary

smart00456
Location:349 → 380

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1042 → 1124

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:805 → 880

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:711 → 798

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063286549.1 → XP_063142619.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X25
XM_039108195.2 → XP_038964123.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X44

UniProtKB/TrEMBL

A0A8I6ABL7

Conserved Domains (6) summary

smart00456
Location:349 → 380

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1110 → 1192

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:303 → 332

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:955 → 1049

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16666
Location:711 → 799

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039108194.2 → XP_038964122.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X43

UniProtKB/TrEMBL

A0A8I6ABL7

Conserved Domains (6) summary

smart00456
Location:349 → 380

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1138 → 1220

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:303 → 332

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:983 → 1077

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16666
Location:711 → 793

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063286563.1 → XP_063142633.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X38
XM_039108184.2 → XP_038964112.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X24

UniProtKB/TrEMBL

A0A8I6ABL7

Conserved Domains (6) summary

smart00456
Location:361 → 392

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1150 → 1232

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:303 → 332

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:995 → 1089

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16666
Location:723 → 805

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063286565.1 → XP_063142635.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X39
XM_063286557.1 → XP_063142627.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X31
XM_063286562.1 → XP_063142632.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X37
XM_063286550.1 → XP_063142620.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X26
XM_063286548.1 → XP_063142618.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X23
XM_039108182.2 → XP_038964110.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

UniProtKB/TrEMBL

A0A8I6ABL7

Conserved Domains (6) summary

smart00456
Location:362 → 393

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1152 → 1234

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:303 → 332

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:996 → 1091

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16666
Location:724 → 806

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063286541.1 → XP_063142611.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X6
XM_039108176.2 → XP_038964104.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (6) summary

smart00456
Location:361 → 392

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1150 → 1232

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:994 → 1089

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:723 → 804

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063286551.1 → XP_063142621.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X27
XM_039108175.2 → XP_038964103.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (6) summary

smart00456
Location:362 → 393

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1151 → 1233

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:995 → 1090

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:724 → 805

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039108193.2 → XP_038964121.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X16

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (6) summary

smart00456
Location:349 → 380

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1110 → 1192

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:955 → 1049

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:711 → 799

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063286543.1 → XP_063142613.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14
XM_006236929.5 → XP_006236991.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (6) summary

smart00228
Location:1138 → 1220

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:303 → 332

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:983 → 1077

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:349 → 378

WW; WW domain

pfam16666
Location:709 → 792

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039108177.2 → XP_038964105.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (6) summary

smart00456
Location:349 → 380

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1139 → 1221

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:983 → 1078

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:711 → 793

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063286547.1 → XP_063142617.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X20
XM_063286545.1 → XP_063142615.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X17
XM_063286544.1 → XP_063142614.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X15
XM_008763133.4 → XP_008761355.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X12

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (6) summary

smart00228
Location:1122 → 1204

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:303 → 332

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:967 → 1061

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:361 → 390

WW; WW domain

pfam16666
Location:721 → 804

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039108179.2 → XP_038964107.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X11

UniProtKB/TrEMBL

A0A0G2JZE4, F1M7H7

Related

ENSRNOP00000099821.1, ENSRNOT00000164096.1

Conserved Domains (6) summary

smart00456
Location:361 → 392

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1123 → 1205

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:967 → 1062

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:723 → 811

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063286546.1 → XP_063142616.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X19
XM_063286542.1 → XP_063142612.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13
XM_039108178.2 → XP_038964106.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X10

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (6) summary

smart00456
Location:362 → 393

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1124 → 1206

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:968 → 1063

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:724 → 812

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039108181.2 → XP_038964109.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X18

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (6) summary

smart00456
Location:362 → 393

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1084 → 1166

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:847 → 922

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:724 → 806

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_017592832.3 → XP_017448321.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7

UniProtKB/TrEMBL

A0A0G2JZE4
XM_039108174.2 → XP_038964102.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (6) summary

smart00456
Location:362 → 393

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1151 → 1233

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:996 → 1090

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:724 → 806

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039108173.2 → XP_038964101.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (6) summary

smart00456
Location:362 → 393

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1152 → 1234

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:996 → 1091

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:724 → 806

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063286554.1 → XP_063142624.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28
XM_063286553.1 → XP_063142623.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28
XM_063286552.1 → XP_063142622.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28
XM_063286567.1 → XP_063142637.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X42
XM_063286559.1 → XP_063142629.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X33
XM_063286560.1 → XP_063142630.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X34
XM_039108188.2 → XP_038964116.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (7) summary

smart00456
Location:135 → 166

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:925 → 1007

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK12678
Location:1044 → 1253

PRK12678; transcription termination factor Rho; Provisional

cd00992
Location:769 → 864

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:75 → 104

WW; WW domain

pfam16663
Location:1 → 33

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:497 → 579

MAGI_u5; Unstructured region on MAGI
XM_063286566.1 → XP_063142636.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X41
XM_063286555.1 → XP_063142625.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X29
XM_039108191.2 → XP_038964119.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (7) summary

smart00456
Location:135 → 166

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:925 → 1007

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK12678
Location:1044 → 1253

PRK12678; transcription termination factor Rho; Provisional

cd00992
Location:769 → 864

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:75 → 104

WW; WW domain

pfam16663
Location:1 → 33

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:497 → 579

MAGI_u5; Unstructured region on MAGI
XM_063286556.1 → XP_063142626.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X30
XM_039108185.2 → XP_038964113.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

UniProtKB/TrEMBL

A0A0G2JZE4

Conserved Domains (7) summary

smart00456
Location:135 → 166

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:925 → 1007

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK12678
Location:1044 → 1253

PRK12678; transcription termination factor Rho; Provisional

cd00992
Location:769 → 864

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:75 → 104

WW; WW domain

pfam16663
Location:1 → 33

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:497 → 579

MAGI_u5; Unstructured region on MAGI
XM_063286561.1 → XP_063142631.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X36
XM_063286558.1 → XP_063142628.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X32
XM_039108189.2 → XP_038964117.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X35

UniProtKB/Swiss-Prot

Q4L1J4, Q4L1J5

Conserved Domains (6) summary

smart00456
Location:361 → 392

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:1123 → 1205

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:967 → 1062

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:302 → 331

WW; WW domain

pfam16666
Location:723 → 811

MAGI_u5; Unstructured region on MAGI

cl17190
Location:122 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...