Fscn1 fascin actin-bundling protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fscn1provided by RGD
Official Full Name: fascin actin-bundling protein 1provided by RGD
Primary source: RGD:1583309
See related: EnsemblRapid:ENSRNOG00000056585 AllianceGenome:RGD:1583309
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fascin
Summary: Enables actin binding activity. Involved in actin filament bundle assembly; cellular response to cell-matrix adhesion; and liver development. Located in several cellular components, including lamellipodium; ruffle; and stress fiber. Orthologous to human FSCN1 (fascin actin-bundling protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 195.0), Heart (RPKM 103.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (16710601..16723734, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (11597042..11610183, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (13655459..13668595, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy.
Title: SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy.
that Fascin-1 increased rapidly in dorsal root ganglions and spinal cord after chronic constriction injury
Title: Fascin-1 Contributes to Neuropathic Pain by Promoting Inflammation in Rat Spinal Cord.
Filopodia formation by crosslinking of F-actin with fascin in two different binding manners
Title: Filopodia formation by crosslinking of F-actin with fascin in two different binding manners.
Data suggest that fascin 1 is involved in localization of actin-bundling proteins paladin and Eps8 (EGF receptor pathway substrate 8) during spermatogenesis; thus, fascin 1 regulates cytoskeletal filaments in Sertoli cells and in spermatid polarity.
Title: Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis.
There may be a pathological role of fascin in experimental autoimmune neuritis.
Title: Accumulation of fascin+ cells during experimental autoimmune neuritis.
A tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis.
Title: Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain.
the expression of fascin-1 is correlated with the migration activity of hepatoblasts during the early stages of liver development in rats.
Title: Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell junction assembly	IEA Inferred from Electronic Annotation more info
involved_in cell-cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cell-matrix adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of apical/basal cell polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment of apical/basal cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of apical/basal cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in microspike assembly	IEA Inferred from Electronic Annotation more info
involved_in microspike assembly	ISO Inferred from Sequence Orthology more info
involved_in microspike assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in parallel actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in parallel actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lamellipodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of podosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microvillus assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cell projection membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection membrane	IEA Inferred from Electronic Annotation more info
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in microspike	IEA Inferred from Electronic Annotation more info
located_in microspike	ISO Inferred from Sequence Orthology more info
located_in microspike	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in podosome	IEA Inferred from Electronic Annotation more info
located_in podosome	ISO Inferred from Sequence Orthology more info
located_in podosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fascin

Names: fascin homolog 1, actin bundling protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100806.2 → NP_001094276.2 fascin

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

B5DEI1, P85845

UniProtKB/TrEMBL

A0A8I6AK10, A6K1N2

Related

ENSRNOP00000093403.1, ENSRNOT00000102305.2

Conserved Domains (2) summary

cd00257
Location:383 → 493

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...

pfam06268
Location:268 → 378

Fascin; Fascin domain