Crtc1 CREB regulated transcription coactivator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crtc1provided by RGD
Official Full Name: CREB regulated transcription coactivator 1provided by RGD
Primary source: RGD:1589158
See related: EnsemblRapid:ENSRNOG00000022421 AllianceGenome:RGD:1589158
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mect1; TORC1; TORC-1
Summary: Predicted to enable cAMP response element binding protein binding activity and transcription coactivator activity. Involved in positive regulation of dendrite development; positive regulation of long-term synaptic potentiation; and postsynapse to nucleus signaling pathway. Located in dendrite and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Biomarker of middle cerebral artery infarction. Orthologous to human CRTC1 (CREB regulated transcription coactivator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 51.6), Brain (RPKM 45.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (19022171..19080880)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18988197..19046914)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20740746..20798145)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysregulated CRTC1-BDNF signaling pathway in the hippocampus contributes to Abeta oligomer-induced long-term synaptic plasticity and memory impairment.
Title: Dysregulated CRTC1-BDNF signaling pathway in the hippocampus contributes to Aβ oligomer-induced long-term synaptic plasticity and memory impairment.
a specific deletion of mTOR in Sertoli cells was found to cause an upregulation of p-rpS6-S240/S244 (i.e., an activation of rpS6), but not total rpS6, and was associated with blood-testis barrier disruption, epithelial damage, loss of cell polarity, and infertility.
Title: F5-Peptide and mTORC1/rpS6 Effectively Enhance BTB Transport Function in the Testis-Lesson From the Adjudin Model.
The PI3K/AKT pathway in the nucleus accumbens (NAc) of rodents plays a role in the molecular and behavioral adaptations that are induced by alcohol, and that in turn drives alcohol-drinking behaviors.
Title: Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents.
blockade of CRTC1-dependent gene expression in the early, preplaque phase of Alzheimer disease-like pathology provides a molecular basis for the cognitive deficits that figure so prominently in early Alzheimer disease
Title: Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease.
depolarization (which produced a robust increase in Ca(2+) signals) together with cAMP signaling resulted in a synergistic induction of Pacap mRNA through calcineurin and its substrate, cAMP-response element-binding protein (CREB)-regulated transcription coactivator 1.
Title: Balance between cAMP and Ca(2+) signals regulates expression levels of pituitary adenylate cyclase-activating polypeptide gene in neurons.
Our results provide evidence that CREB cofactor CRTC1 translocates into the nucleus of a distinct subset of hippocampal neurons during and following status epilepticus
Title: CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy.
Impaired nuclear translocation in mutated amyloid precursor protein transgenic rat model of Alzheimer disease suggests its contribution to hippocampal-dependent learning and memory.
Title: Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease.
Results indicate that overexpressing SIK1 can phosphorylate CRTC1 and CRTC2 in the norepinephrine (NE)-stimulated pinealocytes. Howeve, the endogenous SIK1 does not appear to be the main regulator of their phosphorylation and intracellular localization.
Title: The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and cellular distribution is independent of endogenous SIK1 in the male rat pinealocyte.
The NR2B-CREB-CRTC1 signaling pathway may play a crucial role in circadian rhythm of pain
Title: Regulation of the NR2B-CREB-CRTC1 Signaling Pathway Contributes to Circadian Pain in Murine Model of Chronic Constriction Injury.
PDGF regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1.
Title: Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE102087 (e-PCR)
- UniSTS:244061

BF386683 (e-PCR)
- UniSTS:243812

D16Rat7 (e-PCR)
- UniSTS:119489

D16KYO1 (e-PCR)
- UniSTS:119254

RH144442 (e-PCR)
- UniSTS:233687

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cAMP response element binding protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding protein binding	IEA Inferred from Electronic Annotation more info
enables cAMP response element binding protein binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
involved_in energy homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in entrainment of circadian clock by photoperiod	IEA Inferred from Electronic Annotation more info
involved_in entrainment of circadian clock by photoperiod	ISO Inferred from Sequence Orthology more info
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane hyperpolarization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CREB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in postsynapse to nucleus signaling pathway	EXP Inferred from Experiment more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CREB-regulated transcription coactivator 1

Names: mucoepidermoid carcinoma translocated 1; mucoepidermoid carcinoma translocated protein 1 homolog; transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047115.3 → NP_001040580.1 CREB-regulated transcription coactivator 1

See identical proteins and their annotated locations for NP_001040580.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q157S1

UniProtKB/TrEMBL

A0A8L2QIY8

Related

ENSRNOP00000030925.7, ENSRNOT00000038057.7

Conserved Domains (4) summary

PTZ00449
Location:170 → 470

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

pfam12884
Location:6 → 66

TORC_N; Transducer of regulated CREB activity, N-terminus

pfam12885
Location:148 → 289

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:555 → 630

TORC_C; Transducer of regulated CREB activity, C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

19022171..19080880

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252936.5 → XP_006252998.1 CREB-regulated transcription coactivator 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZLX6, A0A8L2QIY8

Related

ENSRNOP00000079033.2, ENSRNOT00000096484.2

Conserved Domains (3) summary

pfam12884
Location:6 → 66

TORC_N; Transducer of regulated CREB activity, N terminus

pfam12885
Location:148 → 289

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:526 → 601

TORC_C; Transducer of regulated CREB activity, C terminus
XM_063275726.1 → XP_063131796.1 CREB-regulated transcription coactivator 1 isoform X2
XM_063275729.1 → XP_063131799.1 CREB-regulated transcription coactivator 1 isoform X4
XM_063275727.1 → XP_063131797.1 CREB-regulated transcription coactivator 1 isoform X3