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    Klhdc8b kelch domain containing 8B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306589, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhdc8bprovided by RGD
    Official Full Name
    kelch domain containing 8Bprovided by RGD
    Primary source
    RGD:1359445
    See related
    EnsemblRapid:ENSRNOG00000047867 AllianceGenome:RGD:1359445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mitotic cytokinetic process; mitotic nuclear division; and nuclear chromosome segregation. Predicted to be located in cytosol. Predicted to be active in cellularization cleavage furrow; intercellular bridge; and midbody. Human ortholog(s) of this gene implicated in Hodgkin's lymphoma. Orthologous to human KLHDC8B (kelch domain containing 8B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 96.7), Uterus (RPKM 67.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhdc8b in Genome Data Viewer
    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118020136..118025102, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109141594..109146584, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117232047..117236792, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene interactor of HORMAD1 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ciliary microtubule inner protein 7 Neighboring gene coiled-coil domain containing 71 Neighboring gene laminin subunit beta 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitotic errors, aneuploidy and micronuclei in Hodgkin lymphoma pathogenesis. Krem MM, et al. Commun Integr Biol, 2013 May 1. PMID 23713010, Free PMC Article
    2. The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability. Krem MM, et al. J Biol Chem, 2012 Nov 9. PMID 22988245, Free PMC Article
    3. Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma. Krem MM, et al. Cell Cycle, 2010 Feb 15. PMID 20107318, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94736

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellularization cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellularization cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellularization cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cellularization cleavage furrow ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intercellular bridge IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    kelch domain-containing protein 8B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007685.1 → NP_001007686.1  kelch domain-containing protein 8B

      See identical proteins and their annotated locations for NP_001007686.1

      Status: VALIDATED

      Source sequence(s)
      BC083777
      UniProtKB/Swiss-Prot
      Q5XIA9
      UniProtKB/TrEMBL
      A6I356
      Related
      ENSRNOP00000095128.2, ENSRNOT00000101706.2
      Conserved Domains (2) summary
      PHA03098
      Location:9 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118020136..118025102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265323.1 → XP_063121393.1  kelch domain-containing protein 8B isoform X1

    2. XM_039081332.2 → XP_038937260.1  kelch domain-containing protein 8B isoform X2

      Conserved Domains (2) summary
      PHA03098
      Location:2 → 209
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:39 → 81
      Kelch; KELCH repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIA9.1 GenPept UniProtKB/Swiss-Prot:Q5XIA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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