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    Dnajc24 DnaJ heat shock protein family (Hsp40) member C24 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362184, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dnajc24provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C24provided by RGD
    Primary source
    RGD:1564710
    See related
    EnsemblRapid:ENSRNOG00000004842 AllianceGenome:RGD:1564710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dph4; Zcsl3; RGD1564710
    Summary
    Predicted to enable ATPase activator activity; ferrous iron binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of ATP-dependent activity. Orthologous to human DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 67.4), Brain (RPKM 57.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajc24 in Genome Data Viewer
    Location:
    3q33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (112905369..112940741, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (92450631..92486004, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (96025388..96065765, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 4 Neighboring gene uncharacterized LOC120101618 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein L35A like 6 Neighboring gene inner mitochondrial membrane peptidase subunit 1 Neighboring gene doublecortin domain containing 1, pseudogene 1 Neighboring gene doublecortin domain containing 1 Neighboring gene metallophosphoesterase domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4. Thakur A, et al. J Biol Chem, 2012 Apr 13. PMID 22367199, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 24
    Names
    DPH4 homolog (JJJ3, S. cerevisiae)
    DnaJ (Hsp40) homolog, subfamily C, member 24
    zinc finger, CSL-type containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191853.1 → NP_001178782.1  dnaJ homolog subfamily C member 24

      See identical proteins and their annotated locations for NP_001178782.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      F1M2S2
      Related
      ENSRNOP00000006431.6, ENSRNOT00000006431.9
      Conserved Domains (2) summary
      pfam00226
      Location:10 → 78
      DnaJ; DnaJ domain
      pfam05207
      Location:94 → 147
      zf-CSL; CSL zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      112905369..112940741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234654.5 → XP_006234716.1  dnaJ homolog subfamily C member 24 isoform X2

      Related
      ENSRNOP00000099849.1, ENSRNOT00000141988.1
      Conserved Domains (1) summary
      pfam00226
      Location:10 → 78
      DnaJ; DnaJ domain

    2. XM_006234653.5 → XP_006234715.1  dnaJ homolog subfamily C member 24 isoform X1

      See identical proteins and their annotated locations for XP_006234715.1

      UniProtKB/TrEMBL
      F1M2S2
      Conserved Domains (2) summary
      pfam00226
      Location:10 → 78
      DnaJ; DnaJ domain
      pfam05207
      Location:94 → 147
      zf-CSL; CSL zinc finger

    3. XM_063284154.1 → XP_063140224.1  dnaJ homolog subfamily C member 24 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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