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    Tcf7l2 transcription factor 7 like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679869, updated on 3-Dec-2024

    Summary

    Symbol
    Tcf7l2provided by RGD
    Full Name
    transcription factor 7 like 2provided by RGD
    Primary source
    RGD:1583621
    See related
    EnsemblRapid:ENSRNOG00000049232 AllianceGenome:RGD:1583621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables promoter-specific chromatin binding activity. Involved in negative regulation of apoptotic process; negative regulation of gluconeogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of beta-catenin-TCF7L2 complex and protein-DNA complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 33.3), Kidney (RPKM 29.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tcf7l2 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (264791335..264984225)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (254785956..254978967)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (276686911..276730517)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene uncharacterized LOC102554304 Neighboring gene transfer RNA valine (anticodon AAC) 8 Neighboring gene uncharacterized LOC120100061 Neighboring gene uncharacterized LOC134485254 Neighboring gene uncharacterized LOC120100062 Neighboring gene uncharacterized LOC120098090

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables armadillo repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic genitalia morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic hindgut morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within insulin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of DNA repeat elements ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myoblast fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of organ growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type B pancreatic cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of organ growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pituitary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within secretory granule localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skin development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of beta-catenin-TCF7L2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catenin-TCF7L2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of catenin-TCF7L2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription factor 7-like 2
    Names
    transcription factor 7-like 2 (T-cell specific, HMG-box)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415805.2NP_001402734.1  transcription factor 7-like 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A9A2
      Related
      ENSRNOP00000086842.2, ENSRNOT00000101679.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      264791335..264984225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090214.2XP_038946142.1  transcription factor 7-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:406473
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17307
      CTNNB1_binding; N-terminal CTNNB1 binding
    2. XM_039090218.2XP_038946146.1  transcription factor 7-like 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:401468
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17307
      CTNNB1_binding; N-terminal CTNNB1 binding
    3. XM_039090216.2XP_038946144.1  transcription factor 7-like 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:402469
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17307
      CTNNB1_binding; N-terminal CTNNB1 binding
    4. XM_039090221.2XP_038946149.1  transcription factor 7-like 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:397464
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17307
      CTNNB1_binding; N-terminal CTNNB1 binding
    5. XM_039090215.2XP_038946143.1  transcription factor 7-like 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:405472
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17306
      CTNNB1_binding; N-terminal CTNNB1 binding
    6. XM_063273365.1XP_063129435.1  transcription factor 7-like 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A9A2
    7. XM_063273382.1XP_063129452.1  transcription factor 7-like 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Related
      ENSRNOP00000087697.1, ENSRNOT00000100362.2
    8. XM_039090232.2XP_038946160.1  transcription factor 7-like 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:358425
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17259
      CTNNB1_binding; N-terminal CTNNB1 binding
    9. XM_063273464.1XP_063129534.1  transcription factor 7-like 2 isoform X33

    10. XM_063273402.1XP_063129472.1  transcription factor 7-like 2 isoform X14

      UniProtKB/TrEMBL
      A0A8I6A9A2
    11. XM_039090268.2XP_038946196.1  transcription factor 7-like 2 isoform X13

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:358425
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17259
      CTNNB1_binding; N-terminal CTNNB1 binding
    12. XM_039090377.2XP_038946305.1  transcription factor 7-like 2 isoform X38

      UniProtKB/TrEMBL
      A6JI05
      Conserved Domains (2) summary
      cd01388
      Location:358425
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17259
      CTNNB1_binding; N-terminal CTNNB1 binding
    13. XM_039090352.2XP_038946280.1  transcription factor 7-like 2 isoform X34

      Conserved Domains (2) summary
      cd01388
      Location:353420
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17259
      CTNNB1_binding; N-terminal CTNNB1 binding
    14. XM_039090276.2XP_038946204.1  transcription factor 7-like 2 isoform X16

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Related
      ENSRNOP00000092403.2, ENSRNOT00000097397.2
      Conserved Domains (2) summary
      cd01388
      Location:353420
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17259
      CTNNB1_binding; N-terminal CTNNB1 binding
    15. XM_039090271.2XP_038946199.1  transcription factor 7-like 2 isoform X15

      UniProtKB/TrEMBL
      A0A8I6A9A2, A0A8I6AGH1
    16. XM_039090379.2XP_038946307.1  transcription factor 7-like 2 isoform X39

      UniProtKB/TrEMBL
      A0A8I6A761, A6JI05
      Conserved Domains (2) summary
      cd01388
      Location:353420
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17259
      CTNNB1_binding; N-terminal CTNNB1 binding
    17. XM_039090241.2XP_038946169.1  transcription factor 7-like 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:354421
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17259
      CTNNB1_binding; N-terminal CTNNB1 binding
    18. XM_039090263.2XP_038946191.1  transcription factor 7-like 2 isoform X12

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:349416
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17259
      CTNNB1_binding; N-terminal CTNNB1 binding
    19. XM_039090360.2XP_038946288.1  transcription factor 7-like 2 isoform X35

      Conserved Domains (2) summary
      cd01388
      Location:349416
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17259
      CTNNB1_binding; N-terminal CTNNB1 binding
    20. XM_063273415.1XP_063129485.1  transcription factor 7-like 2 isoform X18

      UniProtKB/TrEMBL
      A0A8I6A9A2
    21. XM_039090388.2XP_038946316.1  transcription factor 7-like 2 isoform X41

      UniProtKB/TrEMBL
      A6JI05
      Conserved Domains (2) summary
      cd01388
      Location:349416
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17259
      CTNNB1_binding; N-terminal CTNNB1 binding
    22. XM_039090226.2XP_038946154.1  transcription factor 7-like 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:382449
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17283
      CTNNB1_binding; N-terminal CTNNB1 binding
    23. XM_063273389.1XP_063129459.1  transcription factor 7-like 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A9A2
    24. XM_063273458.1XP_063129528.1  transcription factor 7-like 2 isoform X30

      Related
      ENSRNOP00000107450.1, ENSRNOT00000139917.1
    25. XM_039090344.2XP_038946272.1  transcription factor 7-like 2 isoform X32

      Related
      ENSRNOP00000095963.2, ENSRNOT00000096775.2
    26. XM_039090279.2XP_038946207.1  transcription factor 7-like 2 isoform X17

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Related
      ENSRNOP00000019681.8, ENSRNOT00000019681.8
      Conserved Domains (2) summary
      cd01388
      Location:335402
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    27. XM_039090384.2XP_038946312.1  transcription factor 7-like 2 isoform X40

      UniProtKB/TrEMBL
      A6JI05
      Conserved Domains (2) summary
      cd01388
      Location:335402
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    28. XM_063273435.1XP_063129505.1  transcription factor 7-like 2 isoform X23

      UniProtKB/TrEMBL
      A0A8I6A9A2
    29. XM_039090292.2XP_038946220.1  transcription factor 7-like 2 isoform X22

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:335402
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    30. XM_039090409.2XP_038946337.1  transcription factor 7-like 2 isoform X45

      UniProtKB/TrEMBL
      A6JI05
      Conserved Domains (2) summary
      cd01388
      Location:335402
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    31. XM_039090283.2XP_038946211.1  transcription factor 7-like 2 isoform X20

      UniProtKB/TrEMBL
      A0A8I6A9A2, D3Z9D1
      Conserved Domains (2) summary
      cd01388
      Location:330397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    32. XM_039090393.2XP_038946321.1  transcription factor 7-like 2 isoform X42

      UniProtKB/TrEMBL
      A6JI05
      Conserved Domains (2) summary
      cd01388
      Location:330397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    33. XM_039090300.2XP_038946228.1  transcription factor 7-like 2 isoform X25

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:330397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    34. XM_039090297.2XP_038946225.1  transcription factor 7-like 2 isoform X24

      UniProtKB/TrEMBL
      A0A8I6A9A2, A0A8I6ARM6
      Conserved Domains (2) summary
      cd01388
      Location:330397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    35. XM_039090415.2XP_038946343.1  transcription factor 7-like 2 isoform X46

      UniProtKB/TrEMBL
      A6JI05
      Conserved Domains (2) summary
      cd01388
      Location:330397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    36. XM_063273417.1XP_063129487.1  transcription factor 7-like 2 isoform X19

      UniProtKB/TrEMBL
      A0A8I6A9A2
    37. XM_039090286.2XP_038946214.1  transcription factor 7-like 2 isoform X21

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:326393
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    38. XM_039090397.2XP_038946325.1  transcription factor 7-like 2 isoform X43

      UniProtKB/TrEMBL
      A6JI05
      Conserved Domains (2) summary
      cd01388
      Location:326393
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    39. XM_039090305.2XP_038946233.1  transcription factor 7-like 2 isoform X26

      UniProtKB/TrEMBL
      A0A8I6A9A2
      Conserved Domains (2) summary
      cd01388
      Location:326393
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    40. XM_039090417.2XP_038946345.1  transcription factor 7-like 2 isoform X47

      UniProtKB/TrEMBL
      A6JI05
      Conserved Domains (2) summary
      cd01388
      Location:326393
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    41. XM_039090317.2XP_038946245.1  transcription factor 7-like 2 isoform X28

      Conserved Domains (2) summary
      cd01388
      Location:406473
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17307
      CTNNB1_binding; N-terminal CTNNB1 binding
    42. XM_063273456.1XP_063129526.1  transcription factor 7-like 2 isoform X29

    43. XM_039090306.2XP_038946234.1  transcription factor 7-like 2 isoform X27

      Conserved Domains (2) summary
      cd01388
      Location:406473
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17307
      CTNNB1_binding; N-terminal CTNNB1 binding
    44. XM_063273461.1XP_063129531.1  transcription factor 7-like 2 isoform X31

    45. XM_039090370.2XP_038946298.1  transcription factor 7-like 2 isoform X36

      Conserved Domains (2) summary
      cd01388
      Location:335402
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    46. XM_039090375.2XP_038946303.1  transcription factor 7-like 2 isoform X37

      Related
      ENSRNOP00000106519.1, ENSRNOT00000135924.1
      Conserved Domains (2) summary
      cd01388
      Location:330397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    47. XM_039090403.2XP_038946331.1  transcription factor 7-like 2 isoform X44

      Conserved Domains (2) summary
      cd01388
      Location:326393
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17236
      CTNNB1_binding; N-terminal CTNNB1 binding
    48. XM_063273448.1XP_063129518.1  transcription factor 7-like 2 isoform X27

    RNA

    1. XR_005492199.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191052.2: Suppressed sequence

      Description
      NM_001191052.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.