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    F12 coagulation factor XII [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306761, updated on 27-Nov-2024

    Summary

    Official Symbol
    F12provided by RGD
    Official Full Name
    coagulation factor XIIprovided by RGD
    Primary source
    RGD:1359175
    See related
    EnsemblRapid:ENSRNOG00000015139 AllianceGenome:RGD:1359175
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HAF
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including positive regulation of plasminogen activation; protein maturation; and regulation of blood coagulation. Located in extracellular space. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in angioedema (multiple); cerebrovascular disease (multiple); factor XII deficiency; and myocardial infarction. Orthologous to human F12 (coagulation factor XII). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 1746.7) See more
    Orthologs
    NEW
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    Genomic context

    See F12 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9212819..9220664)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9207683..9215530)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9736577..9744420)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene proline rich 7 (synaptic) Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Factor XII activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Factor XII activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma kallikrein-kinin cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of plasminogen activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to misfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to misfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in zymogen activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zymogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in rough endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    coagulation factor XII
    Names
    factor XII
    hageman factor
    NP_001014028.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014006.1NP_001014028.1  coagulation factor XII precursor

      See identical proteins and their annotated locations for NP_001014028.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088187
      UniProtKB/TrEMBL
      A0A0H2UI19
      Related
      ENSRNOP00000061983.3, ENSRNOT00000066586.4
      Conserved Domains (7) summary
      smart00020
      Location:361597
      Tryp_SPc; Trypsin-like serine protease
      cd00054
      Location:95130
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00061
      Location:132170
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00062
      Location:4087
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00190
      Location:362600
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00008
      Location:177207
      EGF; EGF-like domain
      pfam00051
      Location:216294
      Kringle; Kringle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      9212819..9220664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)