Fnip2 folliculin interacting protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fnip2provided by RGD
Official Full Name: folliculin interacting protein 2provided by RGD
Primary source: RGD:1562174
See related: EnsemblRapid:ENSRNOG00000027833 AllianceGenome:RGD:1562174
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562174
Summary: Predicted to enable ATPase inhibitor activity and protein-folding chaperone binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of TORC1 signaling; and positive regulation of peptidyl-serine phosphorylation. Predicted to act upstream of or within with a positive effect on negative regulation of cell population proliferation. Predicted to be located in centriolar satellite and cytosol. Predicted to be part of FNIP-folliculin RagC/D GAP. Predicted to be active in cytoplasm. Orthologous to human FNIP2 (folliculin interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 286.1), Liver (RPKM 105.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q33

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (166894726..167006490, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (164596557..164708147, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (178223561..178334925, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AU026504 (e-PCR)
- UniSTS:114216

BI276803 (e-PCR)
- UniSTS:249905

RH143438 (e-PCR)
- UniSTS:232685

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of FNIP-folliculin RagC/D GAP	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: folliculin-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271167.1 → NP_001258096.1 folliculin-interacting protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0G2JUW9

Related

ENSRNOP00000031096.7, ENSRNOT00000038543.8

Conserved Domains (3) summary

pfam14636
Location:42 → 162

FNIP_N; Folliculin-interacting protein N-terminus

pfam14637
Location:295 → 528

FNIP_M; Folliculin-interacting protein middle domain

pfam14638
Location:926 → 1109

FNIP_C; Folliculin-interacting protein C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

166894726..167006490 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761100.4 → XP_008759322.1 folliculin-interacting protein 2 isoform X2

UniProtKB/TrEMBL

A0A0G2JUW9

Related

ENSRNOP00000069260.2, ENSRNOT00000090152.3

Conserved Domains (3) summary

pfam14636
Location:42 → 162

FNIP_N; Folliculin-interacting protein N-terminus

pfam14637
Location:325 → 558

FNIP_M; Folliculin-interacting protein middle domain

pfam14638
Location:956 → 1139

FNIP_C; Folliculin-interacting protein C-terminus
XM_008761099.4 → XP_008759321.1 folliculin-interacting protein 2 isoform X1

UniProtKB/TrEMBL

D3Z8I3

Related

ENSRNOP00000103134.1, ENSRNOT00000140385.1

Conserved Domains (3) summary

pfam14636
Location:69 → 189

FNIP_N; Folliculin-interacting protein N-terminus

pfam14637
Location:352 → 585

FNIP_M; Folliculin-interacting protein middle domain

pfam14638
Location:983 → 1166

FNIP_C; Folliculin-interacting protein C-terminus
XM_008761101.4 → XP_008759323.1 folliculin-interacting protein 2 isoform X3

UniProtKB/TrEMBL

A0A8I6AG09

Related

ENSRNOP00000091648.1, ENSRNOT00000104513.2

Conserved Domains (3) summary

pfam14636
Location:69 → 189

FNIP_N; Folliculin-interacting protein N-terminus

pfam14637
Location:322 → 555

FNIP_M; Folliculin-interacting protein middle domain

pfam14638
Location:953 → 1136

FNIP_C; Folliculin-interacting protein C-terminus