Chaf1b chromatin assembly factor 1 subunit B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chaf1bprovided by RGD
Official Full Name: chromatin assembly factor 1 subunit Bprovided by RGD
Primary source: RGD:1307634
See related: EnsemblRapid:ENSRNOG00000001692 AllianceGenome:RGD:1307634
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in DNA replication-dependent chromatin assembly and nucleosome assembly. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of CAF-1 complex. Predicted to be active in nucleus. Orthologous to human CHAF1B (chromatin assembly factor 1 subunit B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 31.6), Spleen (RPKM 18.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (46670560..46690739)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (33200894..33221076)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (34101248..34121371)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC.
Title: DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131285 (e-PCR)
- UniSTS:214568

AFM286zb1 (e-PCR)
- UniSTS:14065

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in DNA replication-dependent chromatin assembly	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CAF-1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CAF-1 complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromatin assembly factor 1 subunit B

Names: chromatin assembly factor 1, subunit B (p60)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024741.1 → NP_001019912.1 chromatin assembly factor 1 subunit B

See identical proteins and their annotated locations for NP_001019912.1

Status: PROVISIONAL

Source sequence(s)

BC097460

UniProtKB/TrEMBL

F7F971, Q4V8B4

Related

ENSRNOP00000002299.4, ENSRNOT00000002299.8

Conserved Domains (3) summary

sd00039
Location:16 → 64

7WD40; WD40 repeat [structural motif]

pfam15512
Location:388 → 561

CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

cl29593
Location:13 → 251

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...