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    Pcare photoreceptor cilium actin regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313891, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pcareprovided by RGD
    Official Full Name
    photoreceptor cilium actin regulatorprovided by RGD
    Primary source
    RGD:1304963
    See related
    EnsemblRapid:ENSRNOG00000008942 AllianceGenome:RGD:1304963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304963
    Summary
    Predicted to be involved in photoreceptor cell outer segment organization and protein localization to photoreceptor outer segment. Predicted to be located in cone photoreceptor outer segment. Predicted to be active in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in retinitis pigmentosa 54. Orthologous to human PCARE (photoreceptor cilium actin regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 84.3) and Muscle (RPKM 29.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcare in Genome Data Viewer
    Location:
    6q14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (29469232..29478541)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (23749700..23758424)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (23337507..23346232)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ALK receptor tyrosine kinase Neighboring gene histidine-rich glycoprotein-like Neighboring gene CAP-GLY domain containing linker protein family, member 4 Neighboring gene CAP-GLY domain containing linker protein family, member 4 Neighboring gene TOG array regulator of axonemal microtubules 2 Neighboring gene small nucleolar RNA, C/D box 53B Neighboring gene WD repeat domain 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. Kevany BM, et al. Hum Mol Genet, 2015 May 1. PMID 25616964, Free PMC Article
    2. Discovery and functional analysis of a retinitis pigmentosa gene, C2ORF71. Nishimura DY, et al. Am J Hum Genet, 2010 May 14. PMID 20398886, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in photoreceptor cell outer segment organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within photoreceptor cell outer segment organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to photoreceptor outer segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cone photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in photoreceptor inner segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in photoreceptor outer segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    photoreceptor cilium actin regulator
    Names
    uncharacterized protein C2orf71 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399236.1 → NP_001386165.1  photoreceptor cilium actin regulator

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Related
      ENSRNOP00000011832.8, ENSRNOT00000011832.9
      Conserved Domains (1) summary
      pfam15449
      Location:1 → 1246
      Retinal; Retinal protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      29469232..29478541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239771.5 → XP_006239833.1  photoreceptor cilium actin regulator isoform X1

      See identical proteins and their annotated locations for XP_006239833.1

      UniProtKB/TrEMBL
      D3ZS67
      Conserved Domains (1) summary
      pfam15449
      Location:1 → 1247
      Retinal; Retinal protein
    Nucleotide Protein Strain
    Heading Accession and Version

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