Coq10a coenzyme Q10A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coq10aprovided by RGD
Official Full Name: coenzyme Q10Aprovided by RGD
Primary source: RGD:1562447
See related: EnsemblRapid:ENSRNOG00000029571 AllianceGenome:RGD:1562447
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562447
Summary: Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration. Predicted to be active in mitochondrion. Orthologous to human COQ10A (coenzyme Q10A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 417.9), Heart (RPKM 194.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1376591..1387694, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (792089..798392, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (2780930..2788189, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulatory effect of exogenous Coenzyme Q10 on redox and inflammatory biomarkers during aging in rats.
Title: Modulatory effect of exogenous Coenzyme Q(10) on redox and inflammatory biomarkers during aging in rats.
Our studies revealed that Coenzyme Q10 strongly inhibits nicotine-mediated production of reactive oxygen species and consequent apoptosis that requires serine36 phosphorylation but not mitochondrial translocation/cytochrome c binding of p66(shc).
Title: Coenzyme Q10 protects renal proximal tubule cells against nicotine-induced apoptosis through induction of p66(shc)-dependent antioxidant responses.
Administration of simvastatin under the condition of nitric oxide-deficiency reduced the level of coenzyme Q9/10 in the heart and skeletal muscle.
Title: Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquinone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular respiration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: coenzyme Q-binding protein COQ10 homolog A, mitochondrial

Names: coenzyme Q10 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108727.1 → NP_001102197.1 coenzyme Q-binding protein COQ10 homolog A, mitochondrial

See identical proteins and their annotated locations for NP_001102197.1

Status: PROVISIONAL

Source sequence(s)

CH474104

UniProtKB/TrEMBL

A6KSC6, D3ZX74

Related

ENSRNOP00000044290.3, ENSRNOT00000047530.6

Conserved Domains (1) summary

cd07813
Location:57 → 195

COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1376591..1387694 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240759.5 → XP_006240821.1 coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006240821.1

UniProtKB/TrEMBL

A6KSC5

Conserved Domains (1) summary

cd07813
Location:89 → 227

COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins
XM_039079365.2 → XP_038935293.1 coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A0G2JYY6

Related

ENSRNOP00000070841.2, ENSRNOT00000086939.3

Conserved Domains (1) summary

cd07813
Location:89 → 237

COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins